Plant-derived small molecule albaconol suppresses LPS-triggered proinflammatory cytokine production and antigen presentation of dendritic cells by impairing NF-kappa B activation

doi:10.1016/j.intimp.2008.04.001

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Plant-derived small molecule albaconol suppresses LPS-triggered proinflammatory cytokine production and antigen presentation of dendritic cells by impairing NF-kappa B activation
	Liu, Qiuyan 2,3; Shu, Xiaoli 4; Sun, Anna 4; Sun, Qiaoling 4; Zhang, Chaoxiong 2,3; An, Huazhang 2,3; Liu, Jikai 1; Cao, Xuetao 2,3,4
刊名	INTERNATIONAL IMMUNOPHARMACOLOGY
	2008-08-01
卷号	8 期号:8 页码:1103-1111
关键词	Dendritic Cell Immunosuppression Inflammation Cytokines Nf-kappa b
ISSN号	1567-5769
DOI	10.1016/j.intimp.2008.04.001
通讯作者	jkl@public.km.yn.cn ; caoxt@public3.sta.net.cn
文献子类	Article
英文摘要	Dendritic cells (DCs) play crucial roles in Linking innate immunity and adaptive immunity, thus being regarded as one of the important targets of immunosuppressant. Natural small molecule products isolated from plants, such as fungal metabolites, have been shown to be effective in the treatment of cancer, inflammation and autoimmune diseases. Albaconol is a new kind of prenylated resorcinols isolated from the fruiting bodies of the inedible mushroom Albatrellus confluens, and has been shown to inhibit tumor cell growth. Considering that most of small molecule compounds with antitumor activity always exert immunosuppressive effect, so we wonder whether albaconol could inhibit maturation and antigen presentation of DCs, thus acting as immunosuppressant. Here we demonstrate that albaconol significantly inhibits LPS-induced production of proinflammatory cytokines TNF-alpha, IL-6, IL-1beta, and expression of MHC-II and co-stimulatory molecules by DCs. Furthermore, albaconol markedly inhibits T cell-stimulating capacity of DCs and DCs-initiated antigen-specific T cell response, indicating albaconol can inhibit phenotypic and functional maturation of DCs. Inhibition of LPS-induced NF-kappa B activation may contribute to the above immunosuppressive or anti-inflammatory activities of albaconol. Therefore, our results suggest that natural small molecule albaconol may be a potential immunosuppressive and anti-inflammatory agent through suppressing DCs function via impairment of NF-kappa B activation. (C) 2008 Elsevier B.V. All rights reserved.
学科主题	Immunology ; Pharmacology & Pharmacy
WOS关键词	MATURATION IN-VITRO ; ALBATRELLUS-CONFLUENS ; TOPOISOMERASE-II ; DIFFERENTIATION ; TOLERANCE ; APOPTOSIS ; VIVO ; INHIBITION ; PATHWAYS
WOS研究方向	Immunology ; Pharmacology & Pharmacy
语种	英语
WOS记录号	WOS:000257577000006
公开日期	2011-12-19
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn:8080/handle/151853/2921]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, Natl Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Second Mil Med Univ, Inst Immunol, Shanghai 200433, Peoples R China 3.Second Mil Med Univ, Natl Key Lab Med Immunol, Shanghai 200433, Peoples R China 4.Zhejiang Univ, Sch Med, Inst Immunol, Hangzhou 310058, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Liu, Qiuyan,Shu, Xiaoli,Sun, Anna,et al. Plant-derived small molecule albaconol suppresses LPS-triggered proinflammatory cytokine production and antigen presentation of dendritic cells by impairing NF-kappa B activation[J]. INTERNATIONAL IMMUNOPHARMACOLOGY,2008,8(8):1103-1111.
APA	Liu, Qiuyan.,Shu, Xiaoli.,Sun, Anna.,Sun, Qiaoling.,Zhang, Chaoxiong.,...&Cao, Xuetao.(2008).Plant-derived small molecule albaconol suppresses LPS-triggered proinflammatory cytokine production and antigen presentation of dendritic cells by impairing NF-kappa B activation.INTERNATIONAL IMMUNOPHARMACOLOGY,8(8),1103-1111.
MLA	Liu, Qiuyan,et al."Plant-derived small molecule albaconol suppresses LPS-triggered proinflammatory cytokine production and antigen presentation of dendritic cells by impairing NF-kappa B activation".INTERNATIONAL IMMUNOPHARMACOLOGY 8.8(2008):1103-1111.