Two new alkaloids and active anti-hepatitis B virus constituents from Hypserpa nitida

doi:10.1016/j.bmcl.2007.08.027

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Two new alkaloids and active anti-hepatitis B virus constituents from Hypserpa nitida
	Cheng, Pi ; Ma, Yun-bao ; Yao, Shu-ying ; Zhang, Quan ; Wang, En-jun ; Yan, Meng-hong ; Zhang, Xue-mei; Zhang, Feng-xue ; Chen, Ji-jun
刊名	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
	2007-10-01
卷号	17 期号:19 页码:5316-5320
关键词	Hipserpa Nitida Menispermaceac Hypserpanine a Hypserpanine b Structure Elucidation Anti-hbv Activity
ISSN号	0960-894X
DOI	10.1016/j.bmcl.2007.08.027
文献子类	Article
英文摘要	Two new alkaloids, hypserpanines A and B (1, 11), together with eleven known compounds, phenolbetain (2), acutumine (3), acutumidine (4), dechloroacutumine (5), dauricumine (6), dauricumidine (7), pronuciferine (8), glaziovine (9), S-reticuline (10), magnoflorine (12) and laurifoline(13), were isolated from Hypserpa nitida Miers. (Menispermaccae) and chemically elucidated through spectral analyses. All the isolated alkaloids were evaluated for their anti-HBV activities in vitro using the HBV transfected Hep G2.2.15 cell line. The most active compound, dauricumidine (7), exhibited an IC50 value of 0.450 mM (SI = 4.13) on hepatitis B virus (HBV) surface antigen (HBsAg) secretion of the Hep G2.2.15 cell line. (C) 2007 Elsevier Ltd. All rights reserved.
学科主题	Chemistry ; Medicinal ; Chemistry ; Organic
WOS关键词	MENISPERMUM-DAURICUM DC ; PROAPORPHINE ALKALOIDS ; PLANTS ; ROOT
WOS研究方向	Pharmacology & Pharmacy ; Chemistry
语种	英语
WOS记录号	WOS:000250041400004
公开日期	2011-11-24
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn:8080/handle/151853/2009]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Kunming Branch, Joint Lab Antiviral Nat Med, Kunming 650204, Yunnam, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 4.Guangzhou Univ Traditat Chinese Med, Inst Trop Med Sci, Guangzhou, Peoples R China
推荐引用方式 GB/T 7714	Cheng, Pi,Ma, Yun-bao,Yao, Shu-ying,et al. Two new alkaloids and active anti-hepatitis B virus constituents from Hypserpa nitida[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2007,17(19):5316-5320.
APA	Cheng, Pi.,Ma, Yun-bao.,Yao, Shu-ying.,Zhang, Quan.,Wang, En-jun.,...&Chen, Ji-jun.(2007).Two new alkaloids and active anti-hepatitis B virus constituents from Hypserpa nitida.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,17(19),5316-5320.
MLA	Cheng, Pi,et al."Two new alkaloids and active anti-hepatitis B virus constituents from Hypserpa nitida".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 17.19(2007):5316-5320.