Synthesis and in vitro anti-hepatitis B virus activities of 4-aryl-6-chloroquinolin-2-one and 5-aryl-7-chloro-1,4-benzodiazepine derivatives

doi:10.1016/j.bmcl.2008.05.065

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	Synthesis and in vitro anti-hepatitis B virus activities of 4-aryl-6-chloroquinolin-2-one and 5-aryl-7-chloro-1,4-benzodiazepine derivatives
	Cheng, Pi 1,2; Zhang, Quan 1,2; Ma, Yun-Bao 1; Jiang, Zhi-Yong 1; Zhang, Xue-Mei1 ; Zhang, Feng-Xue 3; Chen, Ji-Jun1
刊名	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
	2008-07-01
卷号	18 期号:13 页码:3787-3789
关键词	4-aryl-6-chloro-quinolin-2-one Anti-hbv Activity 5-aryl-7-chloro-1 4-benzodiazepine
ISSN号	0960-894X
DOI	10.1016/j.bmcl.2008.05.065
文献子类	Article
英文摘要	A series of 4-aryl-6-chloro-quinolin-2-ones and 5-aryl-7-chloro-1,4-benzodiazepine were synthesized and assayed for their in vitro anti-hepatitis B virus activities and cytotoxicities for the first time. Some of the tested compounds were active against HBsAg and HBeAg secretion in Hep G2.2.15 cells. Compound 5c showed IC(50) of 0.074 and 0.449 mM on HBsAg and HBeAg secretions, respectively, which were 10 times higher than that of its analog 4c and led to better selective index (SI) values (SI = 23.2 and 3.4, respectively). (c) 2008 Elsevier Ltd. All rights reserved.
学科主题	Chemistry ; Medicinal ; Chemistry ; Organic
WOS关键词	EFFICIENT SYNTHESIS ; LAMIVUDINE THERAPY ; 1,4-BENZODIAZEPINES ; QUINAZOLINES ; REARRANGEMENT ; OXAZIRIDINES ; INHIBITORS
WOS研究方向	Pharmacology & Pharmacy ; Chemistry
语种	英语
WOS记录号	WOS:000256708000026
公开日期	2011-11-24
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn:8080/handle/151853/1873]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.Guangzhou Univ Tradit Chinese Med, Inst Trop Med Sci, Guangzhou, Peoples R China
推荐引用方式 GB/T 7714	Cheng, Pi,Zhang, Quan,Ma, Yun-Bao,et al. Synthesis and in vitro anti-hepatitis B virus activities of 4-aryl-6-chloroquinolin-2-one and 5-aryl-7-chloro-1,4-benzodiazepine derivatives[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2008,18(13):3787-3789.
APA	Cheng, Pi.,Zhang, Quan.,Ma, Yun-Bao.,Jiang, Zhi-Yong.,Zhang, Xue-Mei.,...&Chen, Ji-Jun.(2008).Synthesis and in vitro anti-hepatitis B virus activities of 4-aryl-6-chloroquinolin-2-one and 5-aryl-7-chloro-1,4-benzodiazepine derivatives.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,18(13),3787-3789.
MLA	Cheng, Pi,et al."Synthesis and in vitro anti-hepatitis B virus activities of 4-aryl-6-chloroquinolin-2-one and 5-aryl-7-chloro-1,4-benzodiazepine derivatives".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 18.13(2008):3787-3789.