Blockade of cholecystokinin-2 receptor and cyclooxygenase-2 synergistically induces cell apoptosis, and inhibits the proliferation of human gastric cancer cells in vitro | |
Sun, Wei-Hao1; Zhu, Feng2; Chen, Guo-Sheng1; Su, Han3; Luo, Cheng4,5; Zhao, Qin-Shi4; Zhang, Yuan1; Shao, Yun1; Sun, Jian6; Zhou, Su-Ming1 | |
刊名 | CANCER LETTERS |
2008-05-18 | |
卷号 | 263期号:2页码:302-311 |
关键词 | Cholecystokinin-2 Receptor Cyclooxygenase-2 Mkn-45 Cell Proliferation Apoptosis |
ISSN号 | 0304-3835 |
DOI | 10.1016/j.canlet.2008.01.012 |
文献子类 | Article |
英文摘要 | Gastrin and cyclooxygenase-2 (COX-2) play important roles in the carcinogenesis and progression of gastric cancer. However, it remains unknown whether the combination of cholecystokinin-2 (CCK-2) receptor antagonist plus COX-2 inhibitor exerts synergistic anti-tumor effects on human gastric cancer. Here, we demonstrated that the combination of AG-041R (a CCK-2 receptor antagonist) plus NS-398 (a selective COX-2 inhibitor) treatment had synergistic effects on proliferation inhibition, apoptosis induction, down-regulation of Bcl-2 and up-regulation of Bax expression in MKN-45 cells. These results indicate that simultaneous targeting of CCK-2 receptor and COX-2 may inhibit gastric cancer development more effectively than targeting either molecule alone. (C) 2008 Elsevier Ireland Ltd. All rights reserved. |
学科主题 | Oncology |
WOS关键词 | HEPATOCYTE GROWTH-FACTOR ; HELICOBACTER-PYLORI ; EPITHELIAL-CELLS ; SEMIEMPIRICAL METHODS ; HUMAN STOMACH ; UP-REGULATION ; EXPRESSION ; CARCINOMA ; PROTEINS ; BCL-2 |
WOS研究方向 | Oncology |
语种 | 英语 |
WOS记录号 | WOS:000255810500017 |
公开日期 | 2011-11-24 |
内容类型 | 期刊论文 |
源URL | [http://ir.kib.ac.cn:8080/handle/151853/1841] |
专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
作者单位 | 1.Nanjing Med Univ, Affiliated Hosp 1, Dept Geriatr, Nanjing 210029, Jiangsu, Peoples R China 2.Shanghai Jiao Tong Univ, Dept Gastroenterol, Shanghai Peoples Hosp 1, Shanghai 200080, Peoples R China 3.Govt Off Hosp Jiangsu Prov Peoples Govt, Dept Med, Nanjing 210024, Jiangsu, Peoples R China 4.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China 5.Univ Turku, Inst Biomed, FIN-20520 Turku, Finland 6.Univ Hong Kong, Dept Chem, Hong Kong, Hong Kong, Peoples R China |
推荐引用方式 GB/T 7714 | Sun, Wei-Hao,Zhu, Feng,Chen, Guo-Sheng,et al. Blockade of cholecystokinin-2 receptor and cyclooxygenase-2 synergistically induces cell apoptosis, and inhibits the proliferation of human gastric cancer cells in vitro[J]. CANCER LETTERS,2008,263(2):302-311. |
APA | Sun, Wei-Hao.,Zhu, Feng.,Chen, Guo-Sheng.,Su, Han.,Luo, Cheng.,...&Cheng, Yun-Lin.(2008).Blockade of cholecystokinin-2 receptor and cyclooxygenase-2 synergistically induces cell apoptosis, and inhibits the proliferation of human gastric cancer cells in vitro.CANCER LETTERS,263(2),302-311. |
MLA | Sun, Wei-Hao,et al."Blockade of cholecystokinin-2 receptor and cyclooxygenase-2 synergistically induces cell apoptosis, and inhibits the proliferation of human gastric cancer cells in vitro".CANCER LETTERS 263.2(2008):302-311. |
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