Atropurosides A-G, new steroidal saponins from Smilacina atropurpurea

doi:10.1016/j.steroids.2006.04.005

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Atropurosides A-G, new steroidal saponins from Smilacina atropurpurea
	Zhang, Ying ; Li, Hai-Zhou ; Zhang, Ying-Jun; Jacob, Melissa R.; Khan, Shabana I.; Li, Xing-Cong ; Yang, Chong-Ren
刊名	STEROIDS
	2006-08-01
卷号	71 期号:8 页码:712-719
关键词	Smilacina Atropurpurea Steroidal Saponins Atropurosides A-f Antifungal Activities Cytotoxicity
ISSN号	0039-128X
DOI	10.1016/j.steroids.2006.04.005
文献子类	Article
英文摘要	Atropurosides A-G (1-7), seven new steroidal saponins, which possess new polyhydroxylated aglycones, were isolated from the rhizomes of Smilacina atropurpurea (Convallariaceae), together with a known saponin, dioscin (8). Their structures were elucidated on the basis of detailed spectroscopic analysis, including 1D and 2D NMR techniques and chemical methods. Antifungal testing of the eight compounds indicated that atropurosides B (2) and F (6) were fungicidal against Candida albicans, Candida glabrata, Cryptococcus neoformans, and Aspergillus fumigatus with minimum fungicidal concentrations (MFCs) <= 20 mu g/ml, while dioscin (8) was selectively active against C. albicans and C. glabrata (MFC < 5.0 mu g/ml). Furthermore, the antifungal saponins 2, 6, and 8 were evaluated for their in vitro cytotoxicities in a panel of human cancer cell lines (SK-MEL, KB, BT-549, SK-OV-3, and HepG2) and noncancerous Vero cells. All showed moderate cytotoxicities. It appears that the antifungal activity of these steroidal saponins correlates with their cytotoxicity against mammalian cells. (c) 2006 Elsevier Inc. All rights reserved.
学科主题	Biochemistry & Molecular Biology ; Endocrinology & Metabolism
WOS关键词	SAPOGENINS
WOS研究方向	Biochemistry & Molecular Biology ; Endocrinology & Metabolism
语种	英语
WOS记录号	WOS:000239224300010
公开日期	2011-11-24
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn:8080/handle/151853/1835]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China 2.Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, University, MS 38677 USA
推荐引用方式 GB/T 7714	Zhang, Ying,Li, Hai-Zhou,Zhang, Ying-Jun,et al. Atropurosides A-G, new steroidal saponins from Smilacina atropurpurea[J]. STEROIDS,2006,71(8):712-719.
APA	Zhang, Ying.,Li, Hai-Zhou.,Zhang, Ying-Jun.,Jacob, Melissa R..,Khan, Shabana I..,...&Yang, Chong-Ren.(2006).Atropurosides A-G, new steroidal saponins from Smilacina atropurpurea.STEROIDS,71(8),712-719.
MLA	Zhang, Ying,et al."Atropurosides A-G, new steroidal saponins from Smilacina atropurpurea".STEROIDS 71.8(2006):712-719.