Pierisformotoxins A-D, Polyesterified Grayanane Diterpenoids from Pieris formosa and Their cAMP-Decreasing Activities

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	Pierisformotoxins A-D, Polyesterified Grayanane Diterpenoids from Pieris formosa and Their cAMP-Decreasing Activities
	Wang, Wei-Guang 1; Wu, Zhao-Yuan 1; Chen, Rui 2; Li, Hai-Zhou 1; Li, Hong-Mei 1; Li, Yuan-Dan 1; Li, Rong-Tao 1; Luo, Huai-Rong2
刊名	CHEMISTRY & BIODIVERSITY
	2013-06-01
卷号	10 期号:6 页码:1061-1071
关键词	Pieris Formosa Grayanane Diterpenoids Pierisformotoxins A-d Cyclic Adenosine Monophosphate (Camp) Regulation Activity
ISSN号	1612-1872
通讯作者	Li, RT (reprint author), Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming 650050, Peoples R China. ; rongtaolikm@gmail.com ; luohuairong@mail.kib.ac.cn
文献子类	Article
英文摘要	Four highly acylated diterpenoids, designated as pierisformotoxins A-D (1-4, resp.), along with 26 known compounds, were isolated from the flowers of Pieris formosa. Among them, pierisformotoxins A and B (1 and 2, resp.) were new highly acylated grayanane diterpenoids, of which the five-membered ring A has undergone an oxidative cleavage between C(3) and C(4), followed by lactonization, to give rise to a five-membered lactone ring between C(3) and C(5), differing from the previously reported grayanane diterpenoids with a 5/7/6/5 ring system. Results of the cAMP-regulation-activity assay showed that pierisformotoxin C (3) at 10M (inhibitory ratio (IR): 10.1%) or 2M (9.8%), and pierisformotoxin B (2) at 50M (13.9%) significantly decreased the cAMP level in N1E-115 neuroblastoma cells (p<0.05).
学科主题	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS关键词	GRAYANOTOXIN-III ; GLYCOSIDES ; JAPONICA ; CONSTITUENTS ; GLUCOSIDES ; TOXINS ; STEREOSTRUCTURE ; DERIVATIVES ; ACID
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
WOS记录号	WOS:000320543600007
资助机构	National Natural Science Foundation of China [20862011]; Fok Ying-Tong Education Foundation [111040]; Department of Science and Technology in Yunnan Province [20080A007]; Specialized Research Fund for the Doctoral Program of Higher Education [20095314110001]; Fund of State Key Laboratory of Phytochemistry and Plant Resources in West China [P2009-KF05]
公开日期	2013-10-16
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn:8080/handle/151853/16781]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming 650050, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
推荐引用方式 GB/T 7714	Wang, Wei-Guang,Wu, Zhao-Yuan,Chen, Rui,et al. Pierisformotoxins A-D, Polyesterified Grayanane Diterpenoids from Pieris formosa and Their cAMP-Decreasing Activities[J]. CHEMISTRY & BIODIVERSITY,2013,10(6):1061-1071.
APA	Wang, Wei-Guang.,Wu, Zhao-Yuan.,Chen, Rui.,Li, Hai-Zhou.,Li, Hong-Mei.,...&Luo, Huai-Rong.(2013).Pierisformotoxins A-D, Polyesterified Grayanane Diterpenoids from Pieris formosa and Their cAMP-Decreasing Activities.CHEMISTRY & BIODIVERSITY,10(6),1061-1071.
MLA	Wang, Wei-Guang,et al."Pierisformotoxins A-D, Polyesterified Grayanane Diterpenoids from Pieris formosa and Their cAMP-Decreasing Activities".CHEMISTRY & BIODIVERSITY 10.6(2013):1061-1071.