Bioactive ent-Kaurane Diterpenoids from Isodon rosthornii

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Bioactive ent-Kaurane Diterpenoids from Isodon rosthornii
	Zhan, Rui 1,2; Li, Xiao-Nian 1; Du, Xue 1; Wang, Wei-Guang 1; Dong, Ke 1; Su, Jia 1; Li, Yan1 ; Pu, Jian-Xin1 ; Sun, Han-Dong1
刊名	JOURNAL OF NATURAL PRODUCTS
	2013-07-01
卷号	76 期号:7 页码:1267-1277
关键词	Lasiocarpus Hayata Kudo Nf-kappa-b Leukemic-cells Terpenoids Rubescens Differentiation Cytotoxicity Constituents Pharicin
ISSN号	0163-3864
通讯作者	Pu, JX (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China. ; pujianxin@mail.kib.ac.cn ; hdsun@mail.kib.ac.cn
文献子类	Article
英文摘要	Isorosthin A (1), the first 20-nor-enmein-type diterpenoid, and 15 new ent-kauranoids, isorosthins B-P (2-16), along with 22 known analogues were isolated from the aerial parts of Isodon rosthornii. The structures of 1-16 were elucidated by means of spectroscopic analysis. The relative configuration of 2 and the absolute configuration of 3 were determined by single-crystal X-ray diffraction. Cytotoxicity evaluation against five human tumor lines showed inhibitory effects by several of the compounds tested. Furthermore, 12 of the isolates exhibited inhibitory activity against nitric oxide production in LPS-activated RAW264.7 macrophages.
学科主题	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS关键词	LASIOCARPUS HAYATA KUDO ; NF-KAPPA-B ; LEUKEMIC-CELLS ; TERPENOIDS ; RUBESCENS ; DIFFERENTIATION ; CYTOTOXICITY ; CONSTITUENTS ; PHARICIN
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
WOS记录号	WOS:000322562900007
资助机构	National Natural Science Foundation of China [81172939]; Major State Basic Research Development Program of China [2009CB522300]; reservation-talent project of Yunnan Province [2011CI043]; Science and Technology Program of Yunnan Province [2008IF010]; Major Direction Projection Foundation of CAS Intellectual Innovation Project [KSCX2-EW-J-24]; West Light Foundation of the Chinese Academy of Sciences
公开日期	2013-10-16
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn:8080/handle/151853/16745]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Zhan, Rui,Li, Xiao-Nian,Du, Xue,et al. Bioactive ent-Kaurane Diterpenoids from Isodon rosthornii[J]. JOURNAL OF NATURAL PRODUCTS,2013,76(7):1267-1277.
APA	Zhan, Rui.,Li, Xiao-Nian.,Du, Xue.,Wang, Wei-Guang.,Dong, Ke.,...&Sun, Han-Dong.(2013).Bioactive ent-Kaurane Diterpenoids from Isodon rosthornii.JOURNAL OF NATURAL PRODUCTS,76(7),1267-1277.
MLA	Zhan, Rui,et al."Bioactive ent-Kaurane Diterpenoids from Isodon rosthornii".JOURNAL OF NATURAL PRODUCTS 76.7(2013):1267-1277.