Small compound 6-O-angeloylplenolin induces caspase-dependent apoptosis in human multiple myeloma cells

doi:10.3892/ol.2013.1370

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Small compound 6-O-angeloylplenolin induces caspase-dependent apoptosis in human multiple myeloma cells
	Liu, Ying 1,2; Dong, Ying 3; Zhang, Bo 4; Cheng, Yong-Xian 5
刊名	ONCOLOGY LETTERS
	2013-08-01
卷号	6 期号:2 页码:556-558
关键词	6-o-angeloylplenolin Multiple Myeloma Apoptosis Caspase
ISSN号	1792-1074
DOI	10.3892/ol.2013.1370
通讯作者	Liu, Y (reprint author), Tsinghua Univ, Grad Sch Shenzhen, Ctr Biotech & BioMed, Shenzhen Key Lab Gene & Antibody Therapy, Shenzhen 518055, Guangdong, Peoples R China. ; liu.ying2012@sz.tsinghua.edu.cn ; yxcheng@mail.kib.ac.cn
文献子类	Article
英文摘要	6-O-angeloylplenolin (6-OAP) is a sesquiterpene lactone agent that has been previously demonstrated to inhibit the growth of multiple myeloma (MM) cells through mitotic arrest with accumulated cyclin B1. In the present study, the levels of apoptosis were analyzed in dexamethasone-sensitive (MM.1S), dexamethasone-resistant (U266) and chemotherapy-sensitive (RPMI 8226) myeloma cell lines. Enhanced apoptosis was identified following a 48-h incubation with 6-OAP (0-10 mu M) that induced a dose-dependent decrease in pro-casp-3 and the cleavage of its substrate, anti-poly (ADP-ribose) polymerase (PARP). In addition, time-dependent cleavage of PARP was also detected in U266 and MM.1S cells. The mechanism of 6-OAP cytotoxicity in all cell lines was associated with the induction of apoptosis with the presence of cleaved caspase-3 and PARP. In conclusion, 6-OAP-induced apoptosis is caspase-dependent. These observations are likely to provide a framework for future studies of 6-OAP therapy in MM.
学科主题	Oncology
WOS关键词	CENTIPEDA-MINIMA
WOS研究方向	Oncology
语种	英语
WOS记录号	WOS:000322381000049
资助机构	National Natural Science Foundation of China [81101835]; Foundation of Zhejiang Provincial Education Department [Y200804683] ; National Natural Science Foundation of China(81101835) ; Foundation of Zhejiang Provincial Education Department(Y200804683)
公开日期	2013-10-16
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn:8080/handle/151853/16719]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Tsinghua Univ, Grad Sch Shenzhen, Ctr Biotech & BioMed, Shenzhen Key Lab Gene & Antibody Therapy, Shenzhen 518055, Guangdong, Peoples R China 2.Tsinghua Univ, Grad Sch Shenzhen, Div Life Sci, Shenzhen 518055, Guangdong, Peoples R China 3.Zhejiang Univ, Coll Med, Affiliated Hosp 2, Dept Oncol, Hangzhou 310009, Zhejiang, Peoples R China 4.Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China 5.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Liu, Ying,Dong, Ying,Zhang, Bo,et al. Small compound 6-O-angeloylplenolin induces caspase-dependent apoptosis in human multiple myeloma cells[J]. ONCOLOGY LETTERS,2013,6(2):556-558.
APA	Liu, Ying,Dong, Ying,Zhang, Bo,&Cheng, Yong-Xian.(2013).Small compound 6-O-angeloylplenolin induces caspase-dependent apoptosis in human multiple myeloma cells.ONCOLOGY LETTERS,6(2),556-558.
MLA	Liu, Ying,et al."Small compound 6-O-angeloylplenolin induces caspase-dependent apoptosis in human multiple myeloma cells".ONCOLOGY LETTERS 6.2(2013):556-558.