Synthesis and antitumor activities of novel dibenzo[b,d]furan-imidazole hybrid compounds

doi:10.1016/j.ejmech.2013.06.011

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Synthesis and antitumor activities of novel dibenzo[b,d]furan-imidazole hybrid compounds
	Liu, Lan-Xiang 1; Wang, Xue-Quan 1; Yan, Ju-Ming 2; Li, Yan2 ; Sun, Cheng-Jun 1; Chen, Wen 1; Zhou, Bei 1; Zhang, Hong-Bin 1; Yang, Xiao-Dong 1
刊名	EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
	2013-08-01
卷号	66 页码:423-437
关键词	Hybrid Compound Imidazole Dibenzo[b Antitumor Activities d]Furan Structure-activity Relationships
ISSN号	0223-5234
DOI	10.1016/j.ejmech.2013.06.011
通讯作者	Li, Y (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China. ; liyanb@mail.kib.ac.cn ; xdyang@ynu.edu.cn
文献子类	Article
英文摘要	A series of novel hybrid compounds between dibenzo[b,d]furan and imidazole has been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that the existence of benzimidazole ring, and the substitution of the imidazolyl-3-position with a naphthylacyl or 4-methoxyphenacyl group, were vital for modulating cytotoxic activity. In particular, hybrid compound 60 was found to be the most potent derivatives against all of human tumor cell lines investigated, while compound 49 was found to be more selective against breast carcinoma (MCF-7) and myeloid liver carcinoma (SMMC-7721). Compound 60 can induce the G1 phase cell cycle arrest and apoptosis in SMMC-7721 cells. (C) 2013 Elsevier Masson SAS. All rights reserved.
学科主题	Chemistry, Medicinal
WOS关键词	BIOLOGICAL EVALUATION ; NATURAL-PRODUCTS ; DRUG DISCOVERY ; P-TERPHENYLS ; DESIGN ; IMIDAZOLE ; INHIBITORS ; ANALOGS ; CANCER ; AGENTS
WOS研究方向	Pharmacology & Pharmacy
语种	英语
WOS记录号	WOS:000323628500045
资助机构	Natural Science Foundation of China [30960460, 20925205, 21062026]; Natural Science Foundation of Yunnan Province [2012FB113, 2010GA014]; National Basic Research Program of China (973 Program) [2009CB522300]; Project of Recruited Top Talent of Sciences and Technology of Yunnan Province [2009C1120]; CAS ; Natural Science Foundation of China(30960460 ; Natural Science Foundation of Yunnan Province(2012FB113 ; National Basic Research Program of China (973 Program)(2009CB522300) ; Project of Recruited Top Talent of Sciences and Technology of Yunnan Province(2009C1120) ; CAS ; 20925205 ; 2010GA014) ; 21062026)
公开日期	2013-10-16
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn:8080/handle/151853/16709]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Yunnan Univ, Sch Chem Sci & Technol, Minist Educ, Key Lab Med Chem Nat Resource, Kunming 650091, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
推荐引用方式 GB/T 7714	Liu, Lan-Xiang,Wang, Xue-Quan,Yan, Ju-Ming,et al. Synthesis and antitumor activities of novel dibenzo[b,d]furan-imidazole hybrid compounds[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2013,66:423-437.
APA	Liu, Lan-Xiang.,Wang, Xue-Quan.,Yan, Ju-Ming.,Li, Yan.,Sun, Cheng-Jun.,...&Yang, Xiao-Dong.(2013).Synthesis and antitumor activities of novel dibenzo[b,d]furan-imidazole hybrid compounds.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,66,423-437.
MLA	Liu, Lan-Xiang,et al."Synthesis and antitumor activities of novel dibenzo[b,d]furan-imidazole hybrid compounds".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 66(2013):423-437.