Peroxisome-derived lipids are self antigens that stimulate invariant natural killer T cells in the thymus

doi:10.1038/ni.2245

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Peroxisome-derived lipids are self antigens that stimulate invariant natural killer T cells in the thymus
	Federica Facciotti; Gundimeda S Ramanjaneyulu; Marco Lepore; Sebastiano Sansano; Marco Cavallari; Magdalena Kistowska; Sonja Forss-Petter; Guanghui Ni; Alessia Colone; Amit Singhal
刊名	NATURE IMMUNOLOGY
	2012-05-01
卷号	13 期号:5 页码:474-U73
关键词	Anticancer Drug Garcinia Oligantha Xanthone Apoptosis Caspase-3 Derivatives Activation
ISSN号	1529-2908
DOI	10.1038/ni.2245
通讯作者	De Libero, G (reprint author), Univ Basel Hosp, Dept Biomed, CH-4031 Basel, Switzerland, gennaro_delibero@immunol.a-star.edu.sg
文献子类	Article
英文摘要	The development and maturation of semi-invariant natural killer T cells (iNKT cells) rely on the recognition of self antigens presented by CD1d restriction molecules in thymus. The nature of the stimulatory thymic self lipids remains elusive. We isolated lipids from thymocytes and found that ether-bonded mono-alkyl glycerophosphates and the precursors and degradation products of plasmalogens stimulated iNKT cells. Synthetic analogs showed high potency in activating thymic and peripheral iNKT cells. Mice deficient in the peroxisomal enzyme glyceronephosphate O-acyltransferase (GNPAT), essential for the synthesis of ether lipids, had significant alteration of the thymic maturation of iNKT cells and fewer iNKT cells in both thymus and peripheral organs, which confirmed the role of ether-bonded lipids as iNKT cell antigens. Thus, peroxisome-derived lipids are nonredundant self antigens required for the generation of a full iNKT cell repertoire.
学科主题	Immunology
WOS关键词	V-ALPHA-14 NKT CELLS ; MICE ; CD1D ; GLYCOSPHINGOLIPIDS ; BIOSYNTHESIS ; RECOGNITION ; LIGANDS ; INFLAMMATION ; PLASMALOGENS ; HOMEOSTASIS
WOS研究方向	Immunology
语种	英语
WOS记录号	WOS:000303048400011
资助机构	Swiss National Foundation[3100AO-122464/1, Sinergia CRS133-124819]; Yunnan High-End Technology Professionals Introduction Program[2010CI117]; Oncosuisse
公开日期	2012-06-07
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn:8080/handle/151853/10361]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Federica Facciotti,Gundimeda S Ramanjaneyulu,Marco Lepore,et al. Peroxisome-derived lipids are self antigens that stimulate invariant natural killer T cells in the thymus[J]. NATURE IMMUNOLOGY,2012,13(5):474-U73.
APA	Federica Facciotti.,Gundimeda S Ramanjaneyulu.,Marco Lepore.,Sebastiano Sansano.,Marco Cavallari.,...&Gennaro De Libero.(2012).Peroxisome-derived lipids are self antigens that stimulate invariant natural killer T cells in the thymus.NATURE IMMUNOLOGY,13(5),474-U73.
MLA	Federica Facciotti,et al."Peroxisome-derived lipids are self antigens that stimulate invariant natural killer T cells in the thymus".NATURE IMMUNOLOGY 13.5(2012):474-U73.