Synthesis and anticoagulation studies of "short-armed" fucosylated chondroitin sulfate glycoclusters | |
Liu, Huiying1; Zhang, Xiao1; Wu, Mingyi2; Li, Zhongjun1 | |
刊名 | CARBOHYDRATE RESEARCH |
2018-09-01 | |
卷号 | 467页码:45-51 |
关键词 | Fucosylated Chondroitin Sulfate Glycocluster Glycosaminoglycan Anticoagulant Carbohydrate |
ISSN号 | 0008-6215 |
DOI | 10.1016/j.carres.2018.07.008 |
英文摘要 | Fucosylated chondroitin sulfate (FuCS) is a structurally complex glycosaminoglycan found in sea cucumbers with a wide spectrum of biological activities, among which anticoagulant activity is particularly attractive for the development of alternative anticoagulant drugs with decreased adverse effects and risks of bleeding. Previous studies show that FuCS glycomimetics bearing several trisaccharide epitopes displayed promising anticoagulant activity and did not change the mode of action of FuCS. To simplify synthetic difficulty of high valent glycoclusters and obtain candidate compounds with relatively low molecular weights, here we report the synthesis of two FuCS glycoclusters with low valence and more compact structures. Anticoagulation studies showed that these simplified "short-armed" glycoclusters demonstrated comparable potency with "long-armed" high valent glycoclusters, offering a concise approach for the development of novel anticoagulant agents. |
资助项目 | National Natural Science Foundation of China[21472007] ; National Natural Science Foundation of China[21232002] ; National Natural Science Foundation of China[8167330] |
WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
语种 | 英语 |
出版者 | ELSEVIER SCI LTD |
WOS记录号 | WOS:000441886200006 |
资助机构 | National Natural Science Foundation of China |
内容类型 | 期刊论文 |
源URL | [http://ir.kib.ac.cn/handle/151853/62125] |
专题 | 中国科学院昆明植物研究所 |
通讯作者 | Wu, Mingyi; Li, Zhongjun |
作者单位 | 1.Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China |
推荐引用方式 GB/T 7714 | Liu, Huiying,Zhang, Xiao,Wu, Mingyi,et al. Synthesis and anticoagulation studies of "short-armed" fucosylated chondroitin sulfate glycoclusters[J]. CARBOHYDRATE RESEARCH,2018,467:45-51. |
APA | Liu, Huiying,Zhang, Xiao,Wu, Mingyi,&Li, Zhongjun.(2018).Synthesis and anticoagulation studies of "short-armed" fucosylated chondroitin sulfate glycoclusters.CARBOHYDRATE RESEARCH,467,45-51. |
MLA | Liu, Huiying,et al."Synthesis and anticoagulation studies of "short-armed" fucosylated chondroitin sulfate glycoclusters".CARBOHYDRATE RESEARCH 467(2018):45-51. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论