Antioxidant, Anti-Inflammatory and Anti-Influenza Properties of Components from Chaenomeles speciosa

doi:10.3390/molecules15118507

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Antioxidant, Anti-Inflammatory and Anti-Influenza Properties of Components from Chaenomeles speciosa
	Zhang, Li 1; Cheng, Yong-Xian 2; Liu, Ai-Lin 1; Wang, Hai-Di 1; Wang, Ya-Ling 2; Du, Guan-Hua 1
刊名	MOLECULES
	2010-11-01
卷号	15 期号:11 页码:8507-8517
关键词	Chaenomeles Speciosa Antioxidants Anti-inflammatory Na Inhibition
ISSN号	1420-3049
DOI	10.3390/molecules15118507
文献子类	Article
英文摘要	The fruit of Chaenomeles speciosa is a traditional Chinese medicine used for the treatment of dyspepsia and various inflammatory diseases. In the present study, we evaluated the potential radical scavenging capacity, and activity against nitrous oxide, inflammatory cytokines production and neuramindase (NA) of its isolates. The results showed that 3,4-dihydroxybenzoic acid (1) displayed higher inhibitory activities on DPPH and NA with IC(50) values of 1.02 mu g/mL and 1.27 mu g/mL respectively, and quercetin (2) also showed significant inhibitory action on DPPH and NA, with IC50 values of 3.82 mu g/mL and 1.90 mu g/mL. Compounds 1, 2 and methyl 3-hydroxybutanedioic ester (3) could inhibit the production of TNF-alpha by 22.73%, 33.14% and 37.19% at 5 mu g/mL (P < 0.05) compared with the control. In addition, compound 2 was found to be active on the release of IL-6 in RAW264.7 macrophage cells, with an inhibitory rate of 39.79% (P < 0.05). The anti-inflammatory effect of compound 3 is disclosed for the first time in this study. Avian influenza is usually accompanied by virus invasion followed by the occurrence of oxidative stress and serious inflammation, so the multiple effects of the isolates may play a cocktail-like role in the treatment of avian influenza, and C. speciosa components, especially quercetin, might be a potent source for anti-viral and anti-inflammatory agents.
学科主题	Chemistry ; Organic
WOS关键词	VIRUS ; GLUCOSIDES ; EXPRESSION ; ARTHRITIS ; CELLS
WOS研究方向	Chemistry
语种	英语
WOS记录号	WOS:000284582100070
资助机构	Ministry of Science and Technology of China [2009ZX09302-003, 2009ZX09102-123, 2008ZX09401-004]; MOE ; MOHRSS ; Talent Scholarship of Yunnan Youth [2007PY01-48]
公开日期	2011-11-24
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn:8080/handle/151853/1501]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Li,Cheng, Yong-Xian,Liu, Ai-Lin,et al. Antioxidant, Anti-Inflammatory and Anti-Influenza Properties of Components from Chaenomeles speciosa[J]. MOLECULES,2010,15(11):8507-8517.
APA	Zhang, Li,Cheng, Yong-Xian,Liu, Ai-Lin,Wang, Hai-Di,Wang, Ya-Ling,&Du, Guan-Hua.(2010).Antioxidant, Anti-Inflammatory and Anti-Influenza Properties of Components from Chaenomeles speciosa.MOLECULES,15(11),8507-8517.
MLA	Zhang, Li,et al."Antioxidant, Anti-Inflammatory and Anti-Influenza Properties of Components from Chaenomeles speciosa".MOLECULES 15.11(2010):8507-8517.