Bayes factors in the presence of population stratification

doi:10.1016/j.spl.2011.02.020

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	Bayes factors in the presence of population stratification
	Wang, Linglu 2; Li, Qizhai3 ; Li, Zhaohai 2; Zheng, Gang 1
刊名	STATISTICS & PROBABILITY LETTERS
	2011-07-01
卷号	81 期号:7 页码:836-841
关键词	Approximate Bayes factor Clustering Genome-wide association studies Odds ratio Population stratification
ISSN号	0167-7152
DOI	10.1016/j.spl.2011.02.020
英文摘要	Hidden population stratification (PS) is a main concern in the analysis of case-control genetic association studies. All methods to correct for hidden PS have been focused on classical hypothesis testing, and cannot be directly applied to Bayesian analysis. In this paper, to study the impact and the correction of hidden PS on Bayes factor (BF), we use a simple approximation of BF in terms of the maximum likelihood estimates of the odds ratio (OR) and its asymptotic variance. One advantage is that the commonly used principal components analysis method with a large panel of null markers scanned from existing genome-wide association studies can be directly employed to correct for hidden PS in estimating the OR and its asymptotic variance, through which a correction to BF for hidden PS can be achieved. Using simulations, we examine the impact of ignoring hidden PS on BF and show that the proposed method yields an appropriate correction in Bayesian analysis. Published by Elsevier B.V.
资助项目	National Young Science Foundation of China[10901155]
WOS研究方向	Mathematics
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000291175200017
内容类型	期刊论文
源URL	[http://ir.amss.ac.cn/handle/2S8OKBNM/11259]
专题	系统科学研究所
通讯作者	Zheng, Gang
作者单位	1.NHLBI, Off Biostat Res, Bethesda, MD 20892 USA 2.George Washington Univ, Dept Stat, Washington, DC 20052 USA 3.Chinese Acad Sci, Acad Math & Syst Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Wang, Linglu,Li, Qizhai,Li, Zhaohai,et al. Bayes factors in the presence of population stratification[J]. STATISTICS & PROBABILITY LETTERS,2011,81(7):836-841.
APA	Wang, Linglu,Li, Qizhai,Li, Zhaohai,&Zheng, Gang.(2011).Bayes factors in the presence of population stratification.STATISTICS & PROBABILITY LETTERS,81(7),836-841.
MLA	Wang, Linglu,et al."Bayes factors in the presence of population stratification".STATISTICS & PROBABILITY LETTERS 81.7(2011):836-841.