The reactive activities of natural amino acids: key principles of peptide-templated Au cluster synthesis

doi:10.1007/s11434-016-1195-7

	The reactive activities of natural amino acids: key principles of peptide-templated Au cluster synthesis
	Li X(李旭); Li N(李楠); Zhao LN(赵丽娜); Li, X; Li, N; Zhao, LN; Li, Nan; Zhao, Lina
刊名	SCIENCE BULLETIN
	2016
卷号	61 期号:22 页码:1732-1738
关键词	Reactive activity Amino acid Synthesis in situ Au nanocluster DFT calculation
DOI	10.1007/s11434-016-1195-7
通讯作者	赵丽娜
文献子类	期刊论文
英文摘要	Coating of gold nanoclusters with peptides is an important targeting method in biomedical applications. However, their synthetic method highly influences their targeting ability. Current methods often use harsh reagents and organic solvents to control morphology, which are not preferred for biomedical applications. Recently, several peptides with specific amino acid sequences have successfully been used to reduce Au ions and synthesize biocompatible peptide-covered gold particles in situ. However, the molecular mechanism of peptide-assisted nanocluster formation is yet unclear. Thus, reactive abilities of different amino acids should be studied to improve design of peptides with predetermined amino acid content and consequently, synthesize gold nanoclusters with improved performance. In this theoretical study, we have approximated the reactive abilities of 20 natural amino acids in their neutral state using density functional theory calculations, such as Fukui indices and HOMO/LUMO composition analysis. We have found that the top reducing agents are tryptophan, histidine, and tyrosine, and the strongest binding can be expected from methionine and cysteine. Further study of the exact reactive sites in these high reactive amino acids provided the deep insight for the peptide design route for the targeted gold nanocluster formation.
WOS关键词	FLUORESCENT GOLD NANOCLUSTERS ; DIRECTED SYNTHESIS ; ALPHA(IIB)BETA(3) INTEGRIN ; SENSITIVE DETECTION ; CELL ; DESIGN
语种	英语
WOS记录号	WOS:000388645200007
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/260369]
专题	高能物理研究所_多学科研究中心
通讯作者	Zhao, Lina
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Li X,Li N,Zhao LN,et al. The reactive activities of natural amino acids: key principles of peptide-templated Au cluster synthesis[J]. SCIENCE BULLETIN,2016,61(22):1732-1738.
APA	李旭.,李楠.,赵丽娜.,Li, X.,Li, N.,...&Zhao, Lina.(2016).The reactive activities of natural amino acids: key principles of peptide-templated Au cluster synthesis.SCIENCE BULLETIN,61(22),1732-1738.
MLA	李旭,et al."The reactive activities of natural amino acids: key principles of peptide-templated Au cluster synthesis".SCIENCE BULLETIN 61.22(2016):1732-1738.