Gadolinium polytungstate nanoclusters: a new theranostic with ultrasmall size and versatile properties for dual-modal MR/CT imaging and photothermal therapy/radiotherapy of cancer

doi:10.1038/am.2016.63

	Gadolinium polytungstate nanoclusters: a new theranostic with ultrasmall size and versatile properties for dual-modal MR/CT imaging and photothermal therapy/radiotherapy of cancer
	Gu ZJ(谷战军); Zhao, YL; Zhang, GJ; Gu, ZJ; Yan, L; Zhang, SS; Zhou, LJ; Yong, Y; Zhao YL(赵宇亮); Yan L(晏亮)
刊名	NPG ASIA MATERIALS
	2016
卷号	8
DOI	10.1038/am.2016.63
通讯作者	谷战军 ; 赵宇亮
英文摘要	The development of a new generation of nanoscaled theranostics with simple compositions and versatile properties to realize enhanced diagnoses and treatment outcomes and to avoid side effects is highly desirable but remains a great challenge. Here we report a new ultrasmall theranostic based on bovine serum albumin-coated GdW10O36 nanoclusters (GdW10NCs) as multifunctional theranostics for multifunctional bio-imaging, highly effective in vitro photothermal ablation of cancer cells and in vivo radiotherapy of tumors. The as-synthesized GdW10 NCs afford significantly enhanced computed tomography/magnetic resonance imaging signals and remarkable photothermal therapy (PTT)/radiotherapy therapy (RT) therapeutic effects for tumor treatment. Moreover, toxicity studies confirmed their low toxicity and efficient renal clearance, suggesting their potential for practical applications. These results indicated that the as-prepared GdW10 nanoclusters are promising as multifunctional nanotheranostics for multimodal imaging-guided PTT/RT of tumors. These results also encourage the further exploration of other polyoxometalate-based multifunctional nanotheranostics for cancer diagnoses and therapy.
语种	英语
WOS记录号	WOS:000379759400006
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/260308]
专题	高能物理研究所_多学科研究中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Gu ZJ,Zhao, YL,Zhang, GJ,et al. Gadolinium polytungstate nanoclusters: a new theranostic with ultrasmall size and versatile properties for dual-modal MR/CT imaging and photothermal therapy/radiotherapy of cancer[J]. NPG ASIA MATERIALS,2016,8.
APA	谷战军.,Zhao, YL.,Zhang, GJ.,Gu, ZJ.,Yan, L.,...&雍媛.(2016).Gadolinium polytungstate nanoclusters: a new theranostic with ultrasmall size and versatile properties for dual-modal MR/CT imaging and photothermal therapy/radiotherapy of cancer.NPG ASIA MATERIALS,8.
MLA	谷战军,et al."Gadolinium polytungstate nanoclusters: a new theranostic with ultrasmall size and versatile properties for dual-modal MR/CT imaging and photothermal therapy/radiotherapy of cancer".NPG ASIA MATERIALS 8(2016).