Metabolizer in vivo of fullerenes and metallofullerenes by positron emission tomography

doi:10.1088/0957-4484/27/15/155101

	Metabolizer in vivo of fullerenes and metallofullerenes by positron emission tomography
	Xia, L; Chen, K; Bai, X; Yin, WY; Li J(李娟); Gu, WH; Chang, YA; Wang, DL; Cui, RL; Yang, WJ
刊名	NANOTECHNOLOGY
	2016
卷号	27 期号:15
关键词	Cu-64 radiolabeled fullerenes positron emission tomography imaging biodistribution metabolizer
DOI	10.1088/0957-4484/27/15/155101
通讯作者	邢更妹
英文摘要	Fullerenes (C-60) and metallofullerenes (Gd@C-82) have similar chemical structure, but the bio-effects of both fullerene-based materials are. distinct in vivo. Tracking. organic carbon-based materials such as C-60 and Gd@C-82 is difficult in vivo due to the high content of carbon element in the living tissues themselves. In this study, the biodistribution and metabolism of fullerenes (C-60 and Gd@C-82) radiolabeled with Cu-64 were observed by positron emission tomography (PET). Cu-64-C-60 and Cu-64-Gd@C-82 were prepared using 1, 4, 7, 10-tetrakis (carbamoylmethyl)-1, 4, 7, 10-tetra-azacyclodo-decanes grafted on. carbon cages as a. chelator for Cu-64, and were obtained rapidly with high radiochemical yield (>= 90%). The new radio-conjugates were evaluated in vivo in the normal mouse model and. tissue distribution by small animal PET/CT imaging and histology was carried out. The PET imaging, the biodistribution and the excretion of C-60 and Gd@C-82. indicated that C-60 samples have. higher blood retention and. lower renal clearance than the Gd@C-82 samples in vivo and suggested that the differences in. metabolism and distribution in vivo were caused by the structural. differences of the groups on the fullerene cages though there is chemical similarity between C-60 and Gd@C-82.
语种	英语
WOS记录号	WOS:000371343500004
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/260300]
专题	高能物理研究所_多学科研究中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Xia, L,Chen, K,Bai, X,et al. Metabolizer in vivo of fullerenes and metallofullerenes by positron emission tomography[J]. NANOTECHNOLOGY,2016,27(15).
APA	Xia, L.,Chen, K.,Bai, X.,Yin, WY.,李娟.,...&Geng, H.(2016).Metabolizer in vivo of fullerenes and metallofullerenes by positron emission tomography.NANOTECHNOLOGY,27(15).
MLA	Xia, L,et al."Metabolizer in vivo of fullerenes and metallofullerenes by positron emission tomography".NANOTECHNOLOGY 27.15(2016).