Dynamic disorder in receptor-ligand forced dissociation experiments

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	Dynamic disorder in receptor-ligand forced dissociation experiments
	Iwamoto, M; Liu, F; Ou-Yang, ZC; Liu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China
刊名	PHYSICAL REVIEW E
	2006
卷号	73 期号:1 页码:-
关键词	Cell-adhesion Molecules Bonds Catch Transition Kinetics Model
ISSN号	1539-3755
英文摘要	Recently experiments showed that some biological noncovalent bonds increase their lifetimes when they are stretched by an external force, and their lifetimes will decrease when the force increases further. Several specific quantitative models have been proposed to explain the intriguing transitions from the "catch bond" to the "slip bond." In this work we propose that the dynamic disorder of the force-dependent dissociation rate can account for the counterintuitive behaviors of the bonds. A Gaussian stochastic rate model is used to quantitatively describe the transitions observed recently in the single bond P-selctin glycoprotein ligand 1-P-selectin force rupture experiment [Marshall , Nature 423, 190 (2003)]. Our model agrees well with the experimental data. We conclude that the catch bonds could arise from the stronger positive correlation between the height of the intrinsic energy barrier and the distance from the bound state to the barrier; classical pathway scenario or a priori catch bond assumption is not essential.
学科主题	Physics
URL标识	查看原文
WOS记录号	WOS:000235008500007
公开日期	2012-08-02
内容类型	期刊论文
源URL	[http://ir.itp.ac.cn/handle/311006/6064]
专题	理论物理研究所_理论物理所1978-2010年知识产出
通讯作者	Liu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China
推荐引用方式 GB/T 7714	Iwamoto, M,Liu, F,Ou-Yang, ZC,et al. Dynamic disorder in receptor-ligand forced dissociation experiments[J]. PHYSICAL REVIEW E,2006,73(1):-.
APA	Iwamoto, M,Liu, F,Ou-Yang, ZC,&Liu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China.(2006).Dynamic disorder in receptor-ligand forced dissociation experiments.PHYSICAL REVIEW E,73(1),-.
MLA	Iwamoto, M,et al."Dynamic disorder in receptor-ligand forced dissociation experiments".PHYSICAL REVIEW E 73.1(2006):-.