Force unfolding single RNAs

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	Force unfolding single RNAs
	Liu, F; Ou-Yang, ZC; Tong, H; Liu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China
刊名	BIOPHYSICAL JOURNAL
	2006
卷号	90 期号:6 页码:1895-1902
关键词	Free-energy Differences Secondary Structure Mechanical Force Nonequilibrium Measurements Chemical-reactions Molecules Simulations Constants Equality Barriers
ISSN号	0006-3495
英文摘要	We develop a continue time Monte Carlo algorithm to simulate single RNAs unfolded by a time-dependent external force on the secondary structure level. Two recent unfolding RNA experiments carried out by Bustamante group are mainly investigated. We find that, in contrast to popular two-state assumption about the RNAs free energy landscape along the molecular extension, the molecules used in the experiments do not present apparent energy barriers. The strong cooperative folding and unfolding transitions of the RNAs observed in the experiments and in our simulations arise from the interaction of the molecules and the light trap. In addition, we also investigate the properties of Jarzynski's remarkable equality, whose experimental test has received considerable attention.
学科主题	Physics
URL标识	查看原文
WOS记录号	WOS:000235709500005
公开日期	2012-08-02
内容类型	期刊论文
源URL	[http://ir.itp.ac.cn/handle/311006/6025]
专题	理论物理研究所_理论物理所1978-2010年知识产出
通讯作者	Liu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China
推荐引用方式 GB/T 7714	Liu, F,Ou-Yang, ZC,Tong, H,et al. Force unfolding single RNAs[J]. BIOPHYSICAL JOURNAL,2006,90(6):1895-1902.
APA	Liu, F,Ou-Yang, ZC,Tong, H,&Liu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China.(2006).Force unfolding single RNAs.BIOPHYSICAL JOURNAL,90(6),1895-1902.
MLA	Liu, F,et al."Force unfolding single RNAs".BIOPHYSICAL JOURNAL 90.6(2006):1895-1902.