H5N1 avian influenza re-emergence of Lake Communication Qinghai: phylogenetic and antigenic analyses of the newly isolated viruses and roles of migratory birds in virus circulation

	H5N1 avian influenza re-emergence of Lake Communication Qinghai: phylogenetic and antigenic analyses of the newly isolated viruses and roles of migratory birds in virus circulation
	Wang, Guihua 2,3,4,5; Zhan, Dawei 6,7; Li, Laixing 8; Lei, Fumin 9; Liu, Bohua 6,7; Liu, Di 2,3,4,5; Xiao, Haixia 2,3,4,5; Feng, Youjun 2,3,4,5; Li, Jing 6,7; Yang, Baoan 6,7
刊名	journal of general virology
	2008-03-01
卷号	89 期号:march 页码:697-702
关键词	A VIRUS SEQUENCE ALIGNMENT PB1-F2 PROTEIN EVOLUTION WATERFOWL CHINA OUTBREAK SPREAD HOSTS FLU
合作状况	其它
中文摘要	highly pathogenic avian influenza h5n1 virus has swept west across the globe and caused serious debates on the roles of migratory birds in virus circulation since the first large-scale outbreak in migratory birds of lake qinghai, 2005. in may 2006, another outbreak struck lake qinghai and six novel strains were isolated. to elucidate these qh06 viruses, the six isolates were subjected to whole-genome sequencing. phylogenetic analyses show that qh06 viruses are derived from the lineages of lake qinghai, 2005. five of the six novel isolates are adjacent to the strain a/cygnus olor/croatia/1/05, and the last one is related to the strain a/duck/novosibirsk/ 02/05, an isolate of the flyway. antigenic analyses suggest that qh06 and qh05 viruses are similar to each other. these findings implicate that qh06 viruses of lake qinghai may travel back via migratory birds, though not ruling out the possibility of local circulation of viruses of lake qinghai.
英文摘要	highly pathogenic avian influenza h5n1 virus has swept west across the globe and caused serious debates on the roles of migratory birds in virus circulation since the first large-scale outbreak in migratory birds of lake qinghai, 2005. in may 2006, another outbreak struck lake qinghai and six novel strains were isolated. to elucidate these qh06 viruses, the six isolates were subjected to whole-genome sequencing. phylogenetic analyses show that qh06 viruses are derived from the lineages of lake qinghai, 2005. five of the six novel isolates are adjacent to the strain a/cygnus olor/croatia/1/05, and the last one is related to the strain a/duck/novosibirsk/ 02/05, an isolate of the flyway. antigenic analyses suggest that qh06 and qh05 viruses are similar to each other. these findings implicate that qh06 viruses of lake qinghai may travel back via migratory birds, though not ruling out the possibility of local circulation of viruses of lake qinghai.
学科主题	微生物学
WOS标题词	science & technology ; life sciences & biomedicine
类目[WOS]	biotechnology & applied microbiology ; virology
研究领域[WOS]	biotechnology & applied microbiology ; virology
关键词[WOS]	a virus ; sequence alignment ; pb1-f2 protein ; evolution ; waterfowl ; china ; outbreak ; spread ; hosts ; flu
收录类别	SCI
语种	英语
WOS记录号	WOS:000253998700010
公开日期	2009-12-07
内容类型	期刊论文
源URL	[http://ir.nwipb.ac.cn/handle/363003/1228]
专题	西北高原生物研究所_中国科学院西北高原生物研究所
作者单位	1.China Agr Univ, Coll Vet Med, Beijing 100094, Peoples R China 2.Chinese Acad Sci, Inst Microbiol, Ctr Mol Virol, Beijing 100101, Peoples R China 3.Chinese Acad Sci, Inst Microbiol, Ctr Mol Immunol, Beijing 100101, Peoples R China 4.Grad Univ, Chinese Acad Sci, Beijing 100049, Peoples R China 5.Chinese Acad Sci, Inst Microbiol, China Japan Joint Lab Mol Immunol & Mol Microbiol, Beijing 100080, Peoples R China 6.Acad Mil Med Sci, State Key Lab Pathogens & Biosecur, Beijing 100071, Peoples R China 7.Acad Mil Med Sci, Inst Microbiol & Epidemiol, Beijing 100071, Peoples R China 8.Chinese Acad Sci, NW Inst Plateau Biol, Xining 810008, Peoples R China 9.Chinese Acad Sci, Inst Zool, Beijing 100080, Peoples R China 10.Chinese Acad Sci, Beijing Genom Inst, Beijing 101300, Peoples R China
推荐引用方式 GB/T 7714	Wang, Guihua,Zhan, Dawei,Li, Laixing,et al. H5N1 avian influenza re-emergence of Lake Communication Qinghai: phylogenetic and antigenic analyses of the newly isolated viruses and roles of migratory birds in virus circulation[J]. journal of general virology,2008,89(march):697-702.
APA	Wang, Guihua.,Zhan, Dawei.,Li, Laixing.,Lei, Fumin.,Liu, Bohua.,...&Zhu, Qingyu.(2008).H5N1 avian influenza re-emergence of Lake Communication Qinghai: phylogenetic and antigenic analyses of the newly isolated viruses and roles of migratory birds in virus circulation.journal of general virology,89(march),697-702.
MLA	Wang, Guihua,et al."H5N1 avian influenza re-emergence of Lake Communication Qinghai: phylogenetic and antigenic analyses of the newly isolated viruses and roles of migratory birds in virus circulation".journal of general virology 89.march(2008):697-702.