Atomic Force Microscopy in Characterizing Cell Mechanics for Biomedical Applications: A Review

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	Atomic Force Microscopy in Characterizing Cell Mechanics for Biomedical Applications: A Review
	Li M(李密); Dang D(党丹); Liu LQ(刘连庆); Xi N(席宁); Wang YC(王越超)
刊名	IEEE TRANSACTIONS ON NANOBIOSCIENCE
	2017
卷号	16 期号:6 页码:523-540
关键词	Atomic force microscopy cell mechanics Young's modulus biomarker stem cell cancer cell
ISSN号	1536-1241
通讯作者	Li M(李密) ; Liu LQ(刘连庆)
产权排序	1
中文摘要	Cell mechanics is a novel label-free biomarker for indicating cell states and pathological changes. The advent of atomic force microscopy (AFM) provides a powerful tool for quantifying the mechanical properties of single living cells in aqueous conditions. The wide use of AFM in characterizing cell mechanics in the past two decades has yielded remarkable novel insights in understanding the development and progression of certain diseases, such as cancer, showing the huge potential of cell mechanics for practical applications in the field of biomedicine. In this paper, we reviewed the utilization of AFM to characterize cell mechanics. First, the principle and method of AFM single-cell mechanical analysis was presented, along with the mechanical responses of cells to representative external stimuli measured by AFM. Next, the unique changes of cell mechanics in two types of physiological processes (stem cell differentiation, cancer metastasis) revealed by AFM were summarized. After that, the molecular mechanisms guiding cell mechanics were analyzed. Finally the challenges and future directions were discussed.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Biochemical Research Methods ; Nanoscience & Nanotechnology
研究领域[WOS]	Biochemistry & Molecular Biology ; Science & Technology - Other Topics
关键词[WOS]	PLURIPOTENT STEM-CELLS ; PROSTATE-CANCER CELLS ; POWER-LAW RHEOLOGY ; HIGH-SPEED AFM ; LIVING CELLS ; EXTRACELLULAR-MATRIX ; VISCOELASTIC PROPERTIES ; ELASTIC-MODULUS ; BREAST-CANCER ; MICROENVIRONMENTAL REGULATION
收录类别	SCI ; EI
语种	英语
WOS记录号	WOS:000411682900014
内容类型	期刊论文
源URL	[http://ir.sia.cn/handle/173321/21103]
专题	沈阳自动化研究所_机器人学研究室
作者单位	1.Department of Industrial and Manufacturing Systems Engineering, University of Hong Kong, Hong Kong 2.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China
推荐引用方式 GB/T 7714	Li M,Dang D,Liu LQ,et al. Atomic Force Microscopy in Characterizing Cell Mechanics for Biomedical Applications: A Review[J]. IEEE TRANSACTIONS ON NANOBIOSCIENCE,2017,16(6):523-540.
APA	Li M,Dang D,Liu LQ,Xi N,&Wang YC.(2017).Atomic Force Microscopy in Characterizing Cell Mechanics for Biomedical Applications: A Review.IEEE TRANSACTIONS ON NANOBIOSCIENCE,16(6),523-540.
MLA	Li M,et al."Atomic Force Microscopy in Characterizing Cell Mechanics for Biomedical Applications: A Review".IEEE TRANSACTIONS ON NANOBIOSCIENCE 16.6(2017):523-540.