An ensemble learning system for a 4-way classification of Alzheimer's disease and mild cognitive impairment

doi:10.1016/j.jneumeth.2018.03.008

	An ensemble learning system for a 4-way classification of Alzheimer's disease and mild cognitive impairment
	Yao, Dongren1,2,3 ; Calhoun, Vince D.5,6,7; Fu, Zening 5; Du, Yuhui 5,8; Sui, Jing1,2,3,4
刊名	JOURNAL OF NEUROSCIENCE METHODS
	2018-05-15
卷号	302 页码:75-81
关键词	Multi-class Classification Feature Selection Alzheimer's Disease(Ad) Mild Cognitive Impairment (Mci) Structural Mri Hierarchical Classification Relative Importance
DOI	10.1016/j.jneumeth.2018.03.008
文献子类	Article
英文摘要	Discriminating Alzheimer's disease (AD) from its prodromal form, mild cognitive impairment (MCI), is a significant clinical problem that may facilitate early diagnosis and intervention, in which a more challenging issue is to classify MCI subtypes, i.e., those who eventually convert to AD (cMCI) versus those who do not (MCI). To solve this difficult 4-way classification problem (AD, MCI, cMCI and healthy controls), a competition was hosted by Kaggle to invite the scientific community to apply their machine learning approaches on pre-processed sets of T1-weighted magnetic resonance images (MRI) data and the demographic information from the international Alzheimer's disease neuroimaging initiative (ADNI) database. This paper summarizes our competition results. We first proposed a hierarchical process by turning the 4-way classification into five binary classification problems. A new feature selection technology based on relative importance was also proposed, aiming to identify a more informative and concise subset from 426 sMRI morphometric and 3 demographic features, to ensure each binary classifier to achieve its highest accuracy. As a result, about 2% of the original features were selected to build a new feature space, which can achieve the final four-way classification with a 54.38% accuracy on testing data through hierarchical grouping, higher than several alternative methods in comparison. More importantly, the selected discriminative features such as hippocampal volume, parahippocampal surface area, and medial orbitofrontal thickness, etc. as well as the MMSE score, are reasonable and consistent with those reported in AD/MCI deficits. In summary, the proposed method provides a new framework for multi-way classification using hierarchical grouping and precise feature selection. (C) 2018 Elsevier B.V. All rights reserved.
WOS关键词	FEATURE-SELECTION ; MRI ; ASSOCIATION ; ALGORITHM ; ATROPHY
WOS研究方向	Biochemistry & Molecular Biology ; Neurosciences & Neurology
语种	英语
WOS记录号	WOS:000432615900011
资助机构	National High Tech Development Program (863 Plan)(2015AA020513) ; China National Natural Science Foundation(81471367 ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB02060005) ; National Institute of Health(1R01EB00584 ; 61773380) ; 1R01MH094524 ; P20GM103472)
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/22053]
专题	自动化研究所_脑网络组研究中心
作者单位	1.Chinese Acad Sci, Brainnetome Ctr, Beijing, Peoples R China 2.Chinese Acad Sci, NLPR, Inst Automat, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Inst Automat, CAS Ctr Excellence Brain Sci, Beijing, Peoples R China 5.Mind Res Network, Albuquerque, NM USA 6.Univ New Mexico, Dept Psychiat & Neurosci, Albuquerque, NM 87131 USA 7.Univ New Mexico, Dept Elect & Comp Engn, Albuquerque, NM 87131 USA 8.Shanxi Univ, Sch Comp & Informat Technol, Taiyuan, Shanxi, Peoples R China
推荐引用方式 GB/T 7714	Yao, Dongren,Calhoun, Vince D.,Fu, Zening,et al. An ensemble learning system for a 4-way classification of Alzheimer's disease and mild cognitive impairment[J]. JOURNAL OF NEUROSCIENCE METHODS,2018,302:75-81.
APA	Yao, Dongren,Calhoun, Vince D.,Fu, Zening,Du, Yuhui,&Sui, Jing.(2018).An ensemble learning system for a 4-way classification of Alzheimer's disease and mild cognitive impairment.JOURNAL OF NEUROSCIENCE METHODS,302,75-81.
MLA	Yao, Dongren,et al."An ensemble learning system for a 4-way classification of Alzheimer's disease and mild cognitive impairment".JOURNAL OF NEUROSCIENCE METHODS 302(2018):75-81.