The diagnosis of hepatic fibrosis by magnetic resonance and near-infrared imaging using dual-modality nanoparticles

doi:10.1039/c7ra10847h

CORC > 自动化研究所 > 中国科学院自动化研究所 > 中国科学院分子影像重点实验室

	The diagnosis of hepatic fibrosis by magnetic resonance and near-infrared imaging using dual-modality nanoparticles
	Li, Yunfang 1; Shang, Wenting2 ; Liang, Xiaoyuan 2; Zeng, Chaoting 2; Liu, Mingming 1; Wang, Sudan 1; Li, Hongjun 1; Tian, Jie2
刊名	RSC ADVANCES
	2018
卷号	8 期号:12 页码:6699-6708
DOI	10.1039/c7ra10847h
文献子类	Article
英文摘要	Hepatic fibrosis (HF), as the only reversible process of chronic liver disease, remains a big diagnostic challenge. Development of noninvasive and effective methods to assess quantitatively early-stage HF is of great clinical importance. Compared with conventional diagnostic methods, near-infrared fluorescence imaging (NIR) and magnetic resonance imaging (MRI) could offer highly sensitive and spatial resolution signals for HF detection. However, precise detection using contrast agents is not possible. Superparamagnetic iron oxide (SPIO) nanoparticles have low toxicity, high sensitivity and excellent biocompatibility. Integration of Fe3O4 nanoparticles and indocyanine green (ICG), coupled with targeting ligand of integrin alpha(v)beta(3), arginine-glycine-aspartic acid (RGD) expressed on hepatic stellate cells (HSCs), were used to detect HF. Both in vivo and in vitro results showed that the SPIO@SiO2-ICG-RGD had high stability and low cytotoxicity. The biodistribution of SPIO@SiO2-ICG-RGD was significantly different between mice with HF and healthy controls. SPIO@SiO2-ICG-RGD was characterized and the results of imaging in vitro and in vivo demonstrated the expression of integrin alpha(v)beta(3) on activated HSCs. These data suggest that our SPIO@SiO(2)ICG- RGD probe could be used for the diagnosis of early-stage HF. This new nanoprobe with a dualmodality imaging approach holds great potential for the diagnosis and classification of HF.
WOS关键词	INTEGRIN ALPHA-V-BETA-3 EXPRESSION ; LIVER FIBROSIS ; STELLATE CELLS ; INJURY ; APOPTOSIS ; RECEPTOR ; LIGAND ; OXIDE ; RAT ; MRI
WOS研究方向	Chemistry
语种	英语
WOS记录号	WOS:000425034000061
资助机构	Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support(ZYLX201511) ; National Natural Science Foundation of China(81227901 ; Chinese Academy of Sciences(XDB02060010) ; 81501540)
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/21972]
专题	自动化研究所_中国科学院分子影像重点实验室
作者单位	1.Capital Med Univ, Beijing YouAn Hosp, Dept Radiol, 8 Xitoutiao, Beijing 100069, Peoples R China 2.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Zhongguancun East Rd 95, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Li, Yunfang,Shang, Wenting,Liang, Xiaoyuan,et al. The diagnosis of hepatic fibrosis by magnetic resonance and near-infrared imaging using dual-modality nanoparticles[J]. RSC ADVANCES,2018,8(12):6699-6708.
APA	Li, Yunfang.,Shang, Wenting.,Liang, Xiaoyuan.,Zeng, Chaoting.,Liu, Mingming.,...&Tian, Jie.(2018).The diagnosis of hepatic fibrosis by magnetic resonance and near-infrared imaging using dual-modality nanoparticles.RSC ADVANCES,8(12),6699-6708.
MLA	Li, Yunfang,et al."The diagnosis of hepatic fibrosis by magnetic resonance and near-infrared imaging using dual-modality nanoparticles".RSC ADVANCES 8.12(2018):6699-6708.