Longitudinal assessment of fractional anisotropy alterations caused by simian immunodeficiency virus infection: a preliminary diffusion tensor imaging study

doi:10.1007/s13365-015-0388-1

CORC > 自动化研究所 > 中国科学院自动化研究所 > 中国科学院分子影像重点实验室

	Longitudinal assessment of fractional anisotropy alterations caused by simian immunodeficiency virus infection: a preliminary diffusion tensor imaging study
	Tang, Zhenchao 1; Dong, Enqing 1; Liu, Jiaojiao 2; Liu, Zhenyu3 ; Wei, Wenjuan 3; Wang, Bo 4; Li, Hongjun 2; Tian, Jie3
刊名	JOURNAL OF NEUROVIROLOGY
	2016-04-01
卷号	22 期号:2 页码:231-239
关键词	Simian Immunodeficiency Virus Longitudinal Study Diffusion Tensor Imaging Fractional Anisotropy Tract-based Spatial Statistic
DOI	10.1007/s13365-015-0388-1
文献子类	Article
英文摘要	Previous diffusion tensor imaging (DTI) studies found that human immunodeficiency virus (HIV) infection led to white matter (WM) microstructure degeneration. Most of the DTI studies were cross-sectional and thus merely investigated only one specific point in the disease. In order to systematically study the WM impairments caused by HIV infection, more longitudinal studies are needed. However, longitudinal studies on HIV patients are very difficult to conduct. To address this question, we employed the simian immunodeficiency virus (SIV)-infected rhesus monkeys model to carry out a longitudinal DTI study. We aimed to longitudinally access the WM abnormalities of SIV-infected rhesus monkeys by studying the fractional anisotropy (FA) alterations with Tract Based Spatial Statistic (TBSS) analysis. Four rhesus monkeys inoculated intravenously with SIVmac239 were utilized in the study. DTI scans and peripheral blood CD4(+) and CD8(+) T cell counts were acquired prior to virus inoculation (as the baseline) and in the 12th and 24th week postvirus inoculation. Significant FA alterations were found in the two areas of the inferotemporal regions (iTE), respectively located in the ventral subregion of posterior iTE (iTEpv) and the dorsal subregion of iTE (iTEpd). The decreased FA values in iTEpd were found significantly negatively correlated with the elevated peripheral blood CD4(+)/CD8(+) ratios. It might suggest that WM in iTEpd was still impaired even though the immune dysfunction alleviated temporally.
WOS关键词	WHITE-MATTER INTEGRITY ; T-CELL-ACTIVATION ; ANTIRETROVIRAL THERAPY ; HIV-INFECTION ; CORPUS-CALLOSUM ; NEUROCOGNITIVE DISORDERS ; SPATIAL STATISTICS ; NEURAL FRAMEWORK ; RHESUS-MONKEYS ; SIV INFECTION
WOS研究方向	Neurosciences & Neurology ; Virology
语种	英语
WOS记录号	WOS:000371929900011
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/11369]
专题	自动化研究所_中国科学院分子影像重点实验室
通讯作者	Tian, Jie
作者单位	1.Shandong Univ, Sch Mech Elect & Informat Engn, Weihai 264209, Shandong, Peoples R China 2.Capital Med Univ, Beijing YouAn Hosp, Beijing 100069, Peoples R China 3.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China 4.Harbin Univ Sci & Technol, Sch Automat, Harbin 150080, Peoples R China
推荐引用方式 GB/T 7714	Tang, Zhenchao,Dong, Enqing,Liu, Jiaojiao,et al. Longitudinal assessment of fractional anisotropy alterations caused by simian immunodeficiency virus infection: a preliminary diffusion tensor imaging study[J]. JOURNAL OF NEUROVIROLOGY,2016,22(2):231-239.
APA	Tang, Zhenchao.,Dong, Enqing.,Liu, Jiaojiao.,Liu, Zhenyu.,Wei, Wenjuan.,...&Tian, Jie.(2016).Longitudinal assessment of fractional anisotropy alterations caused by simian immunodeficiency virus infection: a preliminary diffusion tensor imaging study.JOURNAL OF NEUROVIROLOGY,22(2),231-239.
MLA	Tang, Zhenchao,et al."Longitudinal assessment of fractional anisotropy alterations caused by simian immunodeficiency virus infection: a preliminary diffusion tensor imaging study".JOURNAL OF NEUROVIROLOGY 22.2(2016):231-239.