Effect of surface properties on liposomal siRNA delivery

doi:10.1016/j.biomaterials.2015.11.056

CORC > 自动化研究所 > 中国科学院自动化研究所 > 中国科学院分子影像重点实验室

	Effect of surface properties on liposomal siRNA delivery
	Xia, Yuqiong 1; Tian, Jie1,2 ; Chen, Xiaoyuan 3
刊名	BIOMATERIALS
	2016-02-01
卷号	79 期号:2015 页码:56-68
关键词	Sirna Delivery Liposomes Surface Charge Pegylation Ligand Modification
DOI	10.1016/j.biomaterials.2015.11.056
文献子类	Review
英文摘要	Liposomes are one of the most widely investigated carriers for siRNA delivery. The surface properties of liposomal carriers, including the surface charge, PEGylation, and ligand modification can significantly affect the gene silencing efficiency. Three barriers of systemic siRNA delivery (long blood circulation, efficient tumor penetration and efficient cellular uptake/endosomal escape) are analyzed on liposomal carriers with different surface charges, PEGylations and ligand modifications. Cationic formulations dominate siRNA delivery and neutral formulations also have good performance while anionic formulations are generally not proper for siRNA delivery. The PEG dilemma (prolonged blood circulation vs. reduced cellular uptake/endosomal escape) and the side effect of repeated PEGylated formulation (accelerated blood clearance) were discussed. Effects of ligand modification on cationic and neutral formulations were analyzed. Finally, we summarized the achievements in liposomal siRNA delivery, outlined existing problems and provided some future perspectives. Published by Elsevier Ltd.
WOS关键词	SMALL INTERFERING RNA ; ACCELERATED BLOOD CLEARANCE ; CALCIUM-PHOSPHATE NANOPARTICLES ; LIPID-LIKE MATERIALS ; PEG IGM PRODUCTION ; IN-VIVO ; GENE DELIVERY ; CANCER-CELLS ; POLY(ETHYLENE GLYCOL) ; CATIONIC LIPOSOMES
WOS研究方向	Engineering ; Materials Science
语种	英语
WOS记录号	WOS:000368868400006
资助机构	program of China Scholarships Council(1408260074) ; Intramural Research Program, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/11336]
专题	自动化研究所_中国科学院分子影像重点实验室
通讯作者	Tian, Jie
作者单位	1.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Shaanxi, Peoples R China 2.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China 3.NIBIB, LOMIN, NIH, Bethesda, MD 20892 USA
推荐引用方式 GB/T 7714	Xia, Yuqiong,Tian, Jie,Chen, Xiaoyuan. Effect of surface properties on liposomal siRNA delivery[J]. BIOMATERIALS,2016,79(2015):56-68.
APA	Xia, Yuqiong,Tian, Jie,&Chen, Xiaoyuan.(2016).Effect of surface properties on liposomal siRNA delivery.BIOMATERIALS,79(2015),56-68.
MLA	Xia, Yuqiong,et al."Effect of surface properties on liposomal siRNA delivery".BIOMATERIALS 79.2015(2016):56-68.