Combining tract- and atlas-based analysis reveals microstructural abnormalities in early Tourette syndrome children

doi:10.1002/hbm.23146

CORC > 自动化研究所 > 中国科学院自动化研究所 > 复杂系统管理与控制国家重点实验室 > 影像分析与机器视觉团队

	Combining tract- and atlas-based analysis reveals microstructural abnormalities in early Tourette syndrome children
	Wen, Hongwei1,2 ; Liu, Yue 3,4; Wang, Jieqiong1 ; Rekik, Islem 5; Zhang, Jishui 3,4; Zhang, Yue 3,4; Tian, Hongwei 3,4; Peng, Yun 3,4; He, Huiguang1,2
刊名	HUMAN BRAIN MAPPING
	2016-05-01
卷号	37 期号:5 页码:1903-1919
关键词	Tourette Syndrome Tract-based Spatial Statistics Atlas-based Roi Analysis Large Deformation Diffeomorphic Metric Mapping Superficial White Matter
DOI	10.1002/hbm.23146
文献子类	Article
英文摘要	Tourette syndrome (TS) is a neurological disorder that causes uncontrolled repetitive motor and vocal tics in children. Examining the neural basis of TS churned out different research studies that advanced our understanding of the brain pathways involved in its development. Particularly, growing evidence points to abnormalities within the fronto-striato-thalamic pathways. In this study, we combined Tract-Based Spatial Statistics (TBSS) and Atlas-based regions of interest (ROI) analysis approach, to investigate the microstructural diffusion changes in both deep and superficial white matter (SWM) in TS children. We then characterized the altered microstructure of white matter in 27 TS children in comparison with 27 age- and gender-matched healthy controls. We found that fractional anisotropy (FA) decreases and radial diffusivity (RD) increases in deep white matter (DWM) tracts in cortico-striato-thalamo-cortical (CSTC) circuit as well as SWM. Furthermore, we found that lower FA values and higher RD values in white matter regions are correlated with more severe tics, but not tics duration. Besides, we also found both axial diffusivity and mean diffusivity increase using Atlas-based ROI analysis. Our work may suggest that microstructural diffusion changes in white matter is not only restricted to the gray matter of CSTC circuit but also affects SWM within the primary motor and somatosensory cortex, commissural and association fibers. Hum Brain Mapp 37:1903-1919, 2016. (c) 2016 Wiley Periodicals, Inc.
WOS关键词	DIFFUSION-TENSOR MRI ; BASAL GANGLIA ; STRUCTURAL CONNECTIVITY ; SPATIAL STATISTICS ; TIC DISORDERS ; AXONAL INJURY ; WHITE-MATTER ; BRAIN ; NETWORKS ; SCALE
WOS研究方向	Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
语种	英语
WOS记录号	WOS:000374840600019
资助机构	National Natural Science Foundation of China(61271151 ; Youth Innovation Promotion Association CAS and Beijing Municipal Administration of Hospitals Incubating Program(PX2016035) ; 91520202 ; 31271161)
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/12211]
专题	自动化研究所_复杂系统管理与控制国家重点实验室_影像分析与机器视觉团队
作者单位	1.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Automat, Res Ctr Brain Inspired Intelligence, Beijing, Peoples R China 3.Capital Med Univ, Beijing Childrens Hosp, Dept Radiol, 56 Nanlishi Rd, Beijing 100045, Peoples R China 4.Capital Med Univ, Beijing Childrens Hosp, Beijing Key Lab Magnet Imaging Device & Tech, Beijing, Peoples R China 5.Univ N Carolina, Dept Radiol & BRIC, Chapel Hill, NC USA
推荐引用方式 GB/T 7714	Wen, Hongwei,Liu, Yue,Wang, Jieqiong,et al. Combining tract- and atlas-based analysis reveals microstructural abnormalities in early Tourette syndrome children[J]. HUMAN BRAIN MAPPING,2016,37(5):1903-1919.
APA	Wen, Hongwei.,Liu, Yue.,Wang, Jieqiong.,Rekik, Islem.,Zhang, Jishui.,...&He, Huiguang.(2016).Combining tract- and atlas-based analysis reveals microstructural abnormalities in early Tourette syndrome children.HUMAN BRAIN MAPPING,37(5),1903-1919.
MLA	Wen, Hongwei,et al."Combining tract- and atlas-based analysis reveals microstructural abnormalities in early Tourette syndrome children".HUMAN BRAIN MAPPING 37.5(2016):1903-1919.