The Default Mode Network Supports Episodic Memory in Cognitively Unimpaired Elderly Individuals: Different Contributions to Immediate Recall and Delayed Recall

doi:10.3389/fnagi.2018.00006

	The Default Mode Network Supports Episodic Memory in Cognitively Unimpaired Elderly Individuals: Different Contributions to Immediate Recall and Delayed Recall
	Huo, Lijuan 1,2; Li, Rui1,2 ; Wang, Pengyun1,2 ; Zheng, Zhiwei1,2 ; Li, Juan1,2 ; Li Juan
刊名	FRONTIERS IN AGING NEUROSCIENCE
	2018-01-24
卷号	10 期号:6 页码:1-10
关键词	immediate recall delayed recall default mode network functional connectivity regional homogeneity
ISSN号	1663-4365
DOI	10.3389/fnagi.2018.00006
产权排序	1
文献子类	Article
英文摘要	While the neural correlates of age-related decline in episodic memory have been the subject of much interest, the spontaneous functional architecture of the brain for various memory processes in elderly adults, such as immediate recall (IR) and delayed recall (DR), remains unclear. The present study thus examined the neural correlates of age-related decline of various memory processes. A total of 66 cognitively normal older adults (aged 60-80 years) participated in this study. Memory processes were measured using the Auditory Verbal Learning Test as well as resting-state brain images, which were analyzed using both regional homogeneity (ReHo) and correlation-based functional connectivity (FC) approaches. We found that both IR and DR were significantly correlated with the ReHo of these critical regions, all within the default mode network (DMN), including the parahippocampal gyrus, posterior cingulate cortex/precuneus, inferior parietal lobule, and medial prefrontal cortex. In addition, DR was also related to the FC between these DMN regions. These results suggest that the DMN plays different roles in memory retrieval across different retention intervals, and connections between the DMN regions contribute to memory consolidation of past events in healthy older people.
WOS关键词	RESTING-STATE FMRI ; ALZHEIMERS-DISEASE ; FUNCTIONAL CONNECTIVITY ; REGIONAL HOMOGENEITY ; AUDITORY-CORTEX ; IMPAIRMENT ; SPEECH ; MRI ; CONSOLIDATION ; HIPPOCAMPAL
WOS研究方向	Geriatrics & Gerontology ; Neurosciences & Neurology
语种	英语
WOS记录号	WOS:000423187800001
资助机构	National Natural Science Foundation of China(31671157 ; Beijing Municipal Science & Technology Commission(Z171100000117006) ; Pioneer Initiative of the Chinese Academy of Sciences, Feature Institutes Program(TSS-2015-06) ; CAS Key Laboratory of Mental Health, Institute of Psychology(KLMH2014ZK02 ; 31470998 ; KLMH2014ZG03) ; 61673374 ; 31271108 ; 31200847)
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/25694]
专题	心理研究所_健康与遗传心理学研究室
通讯作者	Li Juan
作者单位	1.Chinese Acad Sci, Inst Psychol, Ctr Aging Psychol, Key Lab Mental Hlth, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Huo, Lijuan,Li, Rui,Wang, Pengyun,et al. The Default Mode Network Supports Episodic Memory in Cognitively Unimpaired Elderly Individuals: Different Contributions to Immediate Recall and Delayed Recall[J]. FRONTIERS IN AGING NEUROSCIENCE,2018,10(6):1-10.
APA	Huo, Lijuan,Li, Rui,Wang, Pengyun,Zheng, Zhiwei,Li, Juan,&Li Juan.(2018).The Default Mode Network Supports Episodic Memory in Cognitively Unimpaired Elderly Individuals: Different Contributions to Immediate Recall and Delayed Recall.FRONTIERS IN AGING NEUROSCIENCE,10(6),1-10.
MLA	Huo, Lijuan,et al."The Default Mode Network Supports Episodic Memory in Cognitively Unimpaired Elderly Individuals: Different Contributions to Immediate Recall and Delayed Recall".FRONTIERS IN AGING NEUROSCIENCE 10.6(2018):1-10.