Brain-derived neurotrophic factor signalling mediates antidepressant effects of lamotrigine

	Brain-derived neurotrophic factor signalling mediates antidepressant effects of lamotrigine
	Li, Nanxin 1,2; He, Xiaolu 1; Zhang, Yu 1; Qi, Xiaoli3 ; Li, Huijie3 ; Zhu, Xinhong 4; He, Shuchang 1; Li, NX (reprint author), Peking Univ, Dept Psychol, Beijing 100871, Peoples R China.
刊名	INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
	2011-09-01
卷号	14 期号:8 页码:1091-1098
关键词	Antidepressant BDNF CUS FST lamotrigine NSFT
ISSN号	1461-1457
产权排序	3
文献子类	Article
英文摘要	The anticonvulsant drug lamotrigine has been shown to produce antidepressant effects in patients with bipolar disorder. To date, only a few preclinical studies have been conducted using lamotrigine treatment in the forced swim test (FST), an animal model of depression with low face validity. The underlying mechanisms by which lamotrigine works have not been well characterized either. This study extends earlier work on the role of brain-derived neurotrophic factor (BDNF) in regulating the antidepressant actions of lamotrigine. We showed that in rats subjected to chronic unpredictable stress, chronic administration of 30 mg/kg lamotrigine ameliorates behavioural deficits of stressed rats in both sucrose preference test (SPT) and novelty-suppressed feeding test (NSFT). In parallel, chronic lamotrigine treatment up-regulates frontal and hippocampal BDNF protein expression in both naive and stressed animals, and restores the stress-induced down-regulation of BDNF levels. In addition, inhibition of BDNF signalling by infusion of K252a, an inhibitor of the BDNF receptor TrkB, blocks the antidepressant effects of lamotrigine in SPT, NSFT and FST. Taken together, this study provides further evidence that BDNF is an essential mediator for the antidepressant effects of lamotrigine.
学科主题	Medical Psychology
资助项目	一室李娟课题组
语种	英语
WOS记录号	WOS:000294564500007
资助机构	American Psychological Association ; Natural Science Foundation of China [30870768]
公开日期	2011-11-11
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/6908]
专题	心理研究所_健康与遗传心理学研究室
通讯作者	Li, NX (reprint author), Peking Univ, Dept Psychol, Beijing 100871, Peoples R China.
作者单位	1.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China 2.Yale Univ, Dept Psychol, Div Mol Psychiat, New Haven, CT 06520 USA 3.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China 4.So Med Univ, Dept Anat & Neurobiol, Guangzhou, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Li, Nanxin,He, Xiaolu,Zhang, Yu,et al. Brain-derived neurotrophic factor signalling mediates antidepressant effects of lamotrigine[J]. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY,2011,14(8):1091-1098.
APA	Li, Nanxin.,He, Xiaolu.,Zhang, Yu.,Qi, Xiaoli.,Li, Huijie.,...&Li, NX .(2011).Brain-derived neurotrophic factor signalling mediates antidepressant effects of lamotrigine.INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY,14(8),1091-1098.
MLA	Li, Nanxin,et al."Brain-derived neurotrophic factor signalling mediates antidepressant effects of lamotrigine".INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY 14.8(2011):1091-1098.