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	Pubertal isolation alters latent inhibition and DA in nucleus accumbens of adult rats
	Shao, Feng2; Jin, Jian2; Meng, Qingxuan2; Liu, Mei2; Xie, Xi1; Lin, Wenjuan1; Wang, Weiwen1; W. W. Wang
刊名	PHYSIOLOGY & BEHAVIOR
	2009-09-07
卷号	98期号:3页码:251-257
关键词	Social isolation Puberty Schizophrenia Latent inhibition Open field DA Nucleus accumbens
ISSN号	0031-9384
文献子类	Article
英文摘要	Puberty is a critical period for neurodevelopment of schizophrenia. In the present study, we investigated the effects of peri-pubertal social isolation on psychotic behaviors in rats and its relationship to dopamine expression. Wistar male rats were randomly divided into pubertal isolation (ISO: isolate housing, 38-51 days of age) and social (SOC) groups. Latent inhibition (LI) and behavior in open field were tested during adolescence and adulthood. After the behavioral test, dopamine (DA) levels were measured in the medial prefrontal cortex (mPFC), nucleus accumbens (NAC), caudate-putamen (CPU), and the hippocampus (HIP). Pubertal social isolation impaired LI and increased the DA level in the NAC of young adult rats, but not adolescent rats, and enhanced open field locomotor activity in both adolescent and young adult rats. These data suggest that development of an LI deficit can be induced by social isolation during puberty after a developmental delay, and that NAC DA maybe involved in this process, which may mirror some aspects of the ontogency of schizophrenic symptoms.; Puberty is a critical period for neurodevelopment of schizophrenia. In the present study, we investigated the effects of peri-pubertal social isolation on psychotic behaviors in rats and its relationship to dopamine expression. Wistar male rats were randomly divided into pubertal isolation (ISO: isolate housing, 38-51 days of age) and social (SOC) groups. Latent inhibition (LI) and behavior in open field were tested during adolescence and adulthood. After the behavioral test, dopamine (DA) levels were measured in the medial prefrontal cortex (mPFC), nucleus accumbens (NAC), caudate-putamen (CPU), and the hippocampus (HIP). Pubertal social isolation impaired LI and increased the DA level in the NAC of young adult rats, but not adolescent rats, and enhanced open field locomotor activity in both adolescent and young adult rats. These data suggest that development of an LI deficit can be induced by social isolation during puberty after a developmental delay, and that NAC DA maybe involved in this process, which may mirror some aspects of the ontogency of schizophrenic symptoms. (c) 2009 Elsevier Inc. All rights reserved.
学科主题	生理心理学/生物心理学
语种	英语
WOS记录号	WOS:000269571600001
公开日期	2011-08-22
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/5650]
专题	心理研究所_中国科学院心理研究所回溯数据库(1956-2010)
通讯作者	W. W. Wang
作者单位	1.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China 2.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China
推荐引用方式 GB/T 7714	Shao, Feng,Jin, Jian,Meng, Qingxuan,et al. Pubertal isolation alters latent inhibition and DA in nucleus accumbens of adult rats[J]. PHYSIOLOGY & BEHAVIOR,2009,98(3):251-257.
APA	Shao, Feng.,Jin, Jian.,Meng, Qingxuan.,Liu, Mei.,Xie, Xi.,...&W. W. Wang.(2009).Pubertal isolation alters latent inhibition and DA in nucleus accumbens of adult rats.PHYSIOLOGY & BEHAVIOR,98(3),251-257.
MLA	Shao, Feng,et al."Pubertal isolation alters latent inhibition and DA in nucleus accumbens of adult rats".PHYSIOLOGY & BEHAVIOR 98.3(2009):251-257.

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