Orexin A attenuates unconditioned sexual motivation in male rats

CORC > 心理研究所 > 中国科学院心理研究所 > 中国科学院心理研究所回溯数据库(1956-2010)

	Orexin A attenuates unconditioned sexual motivation in male rats
	Bai, Y. J.1,2; Li, Y. H.1; Zheng, X. G.1; Han, J.1,2; Yang, X. Y.1; Sui, N.1 ; N. Sui
刊名	PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
	2009-02-01
卷号	91 期号:4 页码:581-589
关键词	Unconditioned sexual motivation Orexin Preference score Intracerebroventricle
ISSN号	0091-3057
文献子类	Article
英文摘要	Orexins are neuropeptides involved in multiple neurophysiological functions such as reward and motivation. However, it is not clear whether orexins are implicated in sexual motivation. This study aims to evaluate the effects of orexin A and the OX1R antagonist SB334867 on unconditioned sexual motivation. Forty-five male Wistar rats are divided into four groups. The four groups are respectively administered intracerebroventricularly with saline, orexin A (1, 10 mu g), 10% DMSO (cyclodextrin) and SB334867 (5, 15 mu g) 10- 15 min before sexual motivation tests. The preference for a receptive female to a male in in open arena with two tethered animals is designated as unconditioned sexual motivation. The results show that orexin A reduces the female preference (reducing time in the female zone and/or increasing time in the male zone). the number of visits for the female zone and the total distance traveled in sexually high-motivated males. SB334867 has no effect on the female preference, the number of visits and the distance traveled in either sexually high-motivated or low-motivated males. Our experiments reveal that centrally administered orexin A attenuates sexual motivation in high-motivated males although endogenous orexin A might not play an important role in the expression of unconditioned sexual motivation.; Orexins are neuropeptides involved in multiple neurophysiological functions such as reward and motivation. However, it is not clear whether orexins are implicated in sexual motivation. This study aims to evaluate the effects of orexin A and the OX(1)R antagonist SB334867 on unconditioned sexual motivation. Forty-five male Wistar rats are divided into four groups. The four groups are respectively administered intracerebroventricularly with saline, orexin A (1, 10 mu g), 10% DMSO (cyclodextrin) and SB334867 (5, 15 mu g) 10- 15 min before sexual motivation tests. The preference for a receptive female to a male in in open arena with two tethered animals is designated as unconditioned sexual motivation. The results show that orexin A reduces the female preference (reducing time in the female zone and/or increasing time in the male zone). the number of visits for the female zone and the total distance traveled in sexually high-motivated males. SB334867 has no effect on the female preference, the number of visits and the distance traveled in either sexually high-motivated or low-motivated males. Our experiments reveal that centrally administered orexin A attenuates sexual motivation in high-motivated males although endogenous orexin A might not play an important role in the expression of unconditioned sexual motivation. (c) 2008 Elsevier Inc. All rights reserved.
学科主题	生理心理学/生物心理学
语种	英语
WOS记录号	WOS:000263633900015
公开日期	2011-08-22
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/5606]
专题	心理研究所_中国科学院心理研究所回溯数据库(1956-2010)
通讯作者	N. Sui
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Heath, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Bai, Y. J.,Li, Y. H.,Zheng, X. G.,et al. Orexin A attenuates unconditioned sexual motivation in male rats[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2009,91(4):581-589.
APA	Bai, Y. J..,Li, Y. H..,Zheng, X. G..,Han, J..,Yang, X. Y..,...&N. Sui.(2009).Orexin A attenuates unconditioned sexual motivation in male rats.PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,91(4),581-589.
MLA	Bai, Y. J.,et al."Orexin A attenuates unconditioned sexual motivation in male rats".PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 91.4(2009):581-589.