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	Fluoxetine increases the activity of the ERK-CREB signal system and alleviates the depressive-like behavior in rats exposed to chronic forced swim stress
	Qi, Xiaoli1; Lin, Wenjuan1; Li, Junfa2; Li, Huanhuan1; Wang, Weiwen1; Wang, Donglin1; Sun, Meng1; Wenjuan Lin
刊名	NEUROBIOLOGY OF DISEASE
	2008-08-01
卷号	31期号:2页码:278-285
关键词	ERK CREB stress antidepressant hippocampus prefrontal cortex
ISSN号	0969-9961
文献子类	Article
英文摘要	Our previous research indicates that the extracellular signal-regulated kinase (ERK)-cyclic AMP-responsive-element-binding protein (CREB) signal system may be involved in the molecular mechanism of depression. The present study further investigated the effect of antidepressant fluoxetine on the ERK-CREB signal system and the depressive-like behaviors in rats. Fluoxetine was administrated to either naive rats or stressed rats for 21 days. The results showed that chronic forced swim stress induced depressive-like behaviors and decreased the levels of P-ERK2, P-CREB, ERK1/2 and CREB in hippocampus and prefrontal cortex. Fluoxetine alleviated the depressive-like behaviors and reversed the disruptions of the P-ERK2 and P-CREB in stressed rats. Fluoxetine also exerted mood-elevating effect and increased the levels of the P-ERK2 and P-CREB in naive rats. These results suggest that the ERK-CREB signal system may be the targets of the antidepressant action of fluoxetine and participate in the neuronal mechanism of depression.; Our previous research indicates that the extracellular signal-regulated kinase (ERK)-cyclic AMP-responsive-element-binding protein (CREB) signal system may be involved in the molecular mechanism of depression. The present study further investigated the effect of antidepressant fluoxetine on the ERK-CREB signal system and the depressive-like behaviors in rats. Fluoxetine was administrated to either naive rats or stressed rats for 21 days. The results showed that chronic forced swim stress induced depressive-like behaviors and decreased the levels of P-ERK2, P-CREB, ERK1/2 and CREB in hippocampus and prefrontal cortex. Fluoxetine alleviated the depressive-like behaviors and reversed the disruptions of the P-ERK2 and P-CREB in stressed rats. Fluoxetine also exerted mood-elevating effect and increased the levels of the P-ERK2 and P-CREB in naive rats. These results suggest that the ERK-CREB signal system may be the targets of the antidepressant action of fluoxetine and participate in the neuronal mechanism of depression. (C) 2008 Elsevier Inc. All rights reserved.
学科主题	生理心理学/生物心理学
语种	英语
WOS记录号	WOS:000258115700012
公开日期	2011-08-22
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/5414]
专题	心理研究所_中国科学院心理研究所回溯数据库(1956-2010)
通讯作者	Wenjuan Lin
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Capital Med Univ, Beijing 100069, Peoples R China
推荐引用方式 GB/T 7714	Qi, Xiaoli,Lin, Wenjuan,Li, Junfa,et al. Fluoxetine increases the activity of the ERK-CREB signal system and alleviates the depressive-like behavior in rats exposed to chronic forced swim stress[J]. NEUROBIOLOGY OF DISEASE,2008,31(2):278-285.
APA	Qi, Xiaoli.,Lin, Wenjuan.,Li, Junfa.,Li, Huanhuan.,Wang, Weiwen.,...&Wenjuan Lin.(2008).Fluoxetine increases the activity of the ERK-CREB signal system and alleviates the depressive-like behavior in rats exposed to chronic forced swim stress.NEUROBIOLOGY OF DISEASE,31(2),278-285.
MLA	Qi, Xiaoli,et al."Fluoxetine increases the activity of the ERK-CREB signal system and alleviates the depressive-like behavior in rats exposed to chronic forced swim stress".NEUROBIOLOGY OF DISEASE 31.2(2008):278-285.

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