Benzo(a)pyrene-induced metabolic responses in Manila clam Ruditapes philippinarum by proton nuclear magnetic resonance ((1)H NMR) based metabolomics

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 中科院海岸带环境过程与生态修复重点实验室 > 污染过程与控制实验室

	Benzo(a)pyrene-induced metabolic responses in Manila clam Ruditapes philippinarum by proton nuclear magnetic resonance ((1)H NMR) based metabolomics
	Zhang, L ; Liu, XL ; You, LP ; Zhou, D ; Wang, Q ; Li, F ; Cong, M ; Li, LZ ; Zhao, JM ; Liu, DY ; Yu, JB ; Wu, HF
刊名	ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
	2011
卷号	32 期号:2 页码:218-225
关键词	Benzo(a)Pyrene Toxicological Effects Biomarker Manila Clam Nmr Metabolomics Pattern-recognition Nmr Metabolomics Tidal Flats Liver Spectroscopy Metabonomics Extraction Transformation Vitellogenin Biochemistry
ISSN号	1382-6689
通讯作者	Wu, HF (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Zone Environm Proc, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China
产权排序	[Zhang, Linbao; Liu, Xiaoli; You, Liping; Zhou, Di; Wang, Qing; Li, Fei; Cong, Ming; Li, Lianzhen; Zhao, Jianmin; Liu, Dongyan; Yu, Junbao; Wu, Huifeng] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Zone Environm Proc, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China; [Zhang, Linbao; Liu, Xiaoli; You, Liping; Zhou, Di] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
英文摘要	Benzo(a)pyrene is an important polycyclic aromatic hydrocarbon (PAH) which causes carcinogenic, teratogenic and mutagenic effects in various species and the level of contamination of this toxic agent in the marine environment is of great concern. In this study, metabolic responses induced by two doses (0.02 and 0.2 mu M) of BaP were characterized in the gill tissues of Manila clam Ruditapes philippinarum after exposure for 24, 48 and 96h. The high dose (0.2 mu M) of BaP induced the disturbances in energy metabolism and osmotic regulation based on the metabolic biomarkers such as succinate, alanine, glucose, glycogen, branched chain amino acids, betaine, taurine, homarine, and dimethylamine in clam gills after 24 h of exposure. In addition, hormesis induced by BaP was found in clams exposed to both doses of BaP. Overall, our results demonstrated the applicability of metabolomics for the elucidation of toxicological effects of marine environmental contaminants in a selected bioindicator species such as the Manila clam. (C) 2011 Elsevier B.V. All rights reserved.
学科主题	Environmental Sciences & Ecology ; Pharmacology & Pharmacy ; Toxicology
URL标识	查看原文
语种	英语
公开日期	2012-03-06
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/5369]
专题	烟台海岸带研究所_污染过程与控制实验室
推荐引用方式 GB/T 7714	Zhang, L,Liu, XL,You, LP,et al. Benzo(a)pyrene-induced metabolic responses in Manila clam Ruditapes philippinarum by proton nuclear magnetic resonance ((1)H NMR) based metabolomics[J]. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2011,32(2):218-225.
APA	Zhang, L.,Liu, XL.,You, LP.,Zhou, D.,Wang, Q.,...&Wu, HF.(2011).Benzo(a)pyrene-induced metabolic responses in Manila clam Ruditapes philippinarum by proton nuclear magnetic resonance ((1)H NMR) based metabolomics.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,32(2),218-225.
MLA	Zhang, L,et al."Benzo(a)pyrene-induced metabolic responses in Manila clam Ruditapes philippinarum by proton nuclear magnetic resonance ((1)H NMR) based metabolomics".ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 32.2(2011):218-225.