Kiamycin, a Unique Cytotoxic Angucyclinone Derivative from a Marine Streptomyces sp.

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	Kiamycin, a Unique Cytotoxic Angucyclinone Derivative from a Marine Streptomyces sp.
	Xie, Zeping 1,2; Liu, Bing 1; Wang, Hongpeng 3; Yang, Shengxiang 4; Zhang, Hongyu 1,2; Wang, Yipeng1 ; Ji, Naiyun1 ; Qin, Song1 ; Laatsch, Hartmut 3
刊名	MARINE DRUGS
	2012-03-01
卷号	10 期号:3 页码:551-558
关键词	Angucyclinone Epoxybenz[a]Anthracene Marine Streptomyces Cytotoxicity
ISSN号	1660-3397
通讯作者	Qin, S (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China. zpxie@yic.ac.cn ; bliu@yic.ac.cn ; wanghongpeng@hotmail.com ; ysx19821028@yahoo.com.cn ; hyzhang@yic.ac.cn ; ypwang@yic.ac.cn ; nyji@yic.ac.cn ; sqin@yic.ac.cn ; hlaatsc@gwdg.de
产权排序	[Xie, Zeping; Liu, Bing; Zhang, Hongyu; Wang, Yipeng; Ji, Naiyun; Qin, Song] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; [Xie, Zeping; Zhang, Hongyu] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China; [Wang, Hongpeng; Laatsch, Hartmut] Univ Gottingen, Dept Organ & Biomol Chem, D-37077 Gottingen, Germany; [Yang, Shengxiang] NW A&F Univ, Chem Biol Res Inst, Coll Sci, Yangling 712100, Peoples R China
文献子类	Article
英文摘要	Kiamycin (1), a new angucyclinone derivative possessing an 1,12-epoxybenz[a]anthracene ring system, was isolated from the marine Streptomyces sp. strain M268 along with the known compounds 8-O-methyltetrangomycin (3) and 8-O-methylrabelomycin (4). Their structures were elucidated by detailed spectroscopic analysis and comparison with literature data. The new angucyclinone derivative showed inhibitory activities against the human cell lines HL-60 (leukemia), A549 (lung adenocarcinoma), and BEL-7402 (hepatoma) with inhibition rates of 68.2%, 55.9%, and 31.7%, respectively, at 100 mu M. It appears to have potential as an anticancer agent with selective activity.; Kiamycin (1), a new angucyclinone derivative possessing an 1,12-epoxybenz[a]anthracene ring system, was isolated from the marine Streptomyces sp. strain M268 along with the known compounds 8-O-methyltetrangomycin (3) and 8-O-methylrabelomycin (4). Their structures were elucidated by detailed spectroscopic analysis and comparison with literature data. The new angucyclinone derivative showed inhibitory activities against the human cell lines HL-60 (leukemia), A549 (lung adenocarcinoma), and BEL-7402 (hepatoma) with inhibition rates of 68.2%, 55.9%, and 31.7%, respectively, at 100 mu M. It appears to have potential as an anticancer agent with selective activity.
学科主题	Pharmacology & Pharmacy
URL标识	查看原文
WOS关键词	ANTIBIOTICS ; PRODUCTS
WOS研究方向	Pharmacology & Pharmacy
语种	英语
WOS记录号	WOS:000302136700003
资助机构	project of
公开日期	2012-06-13
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/5564]
专题	烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 3.Univ Gottingen, Dept Organ & Biomol Chem, D-37077 Gottingen, Germany 4.NW A&F Univ, Chem Biol Res Inst, Coll Sci, Yangling 712100, Peoples R China
推荐引用方式 GB/T 7714	Xie, Zeping,Liu, Bing,Wang, Hongpeng,et al. Kiamycin, a Unique Cytotoxic Angucyclinone Derivative from a Marine Streptomyces sp.[J]. MARINE DRUGS,2012,10(3):551-558.
APA	Xie, Zeping.,Liu, Bing.,Wang, Hongpeng.,Yang, Shengxiang.,Zhang, Hongyu.,...&Laatsch, Hartmut.(2012).Kiamycin, a Unique Cytotoxic Angucyclinone Derivative from a Marine Streptomyces sp..MARINE DRUGS,10(3),551-558.
MLA	Xie, Zeping,et al."Kiamycin, a Unique Cytotoxic Angucyclinone Derivative from a Marine Streptomyces sp.".MARINE DRUGS 10.3(2012):551-558.