Genome-Wide Analysis of Biotin Biosynthesis in Eukaryotic Photosynthetic Algae

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	Genome-Wide Analysis of Biotin Biosynthesis in Eukaryotic Photosynthetic Algae
	Cui, Hongli 1,2; Wang, Yipeng1 ; Zhang, Hongyu 1,2; Wang, Yinchu1,2 ; Qin, Song1
刊名	PLANT MOLECULAR BIOLOGY REPORTER
	2012-04-01
卷号	30 期号:2 页码:421-432
关键词	Biotin Biosynthesis Molecular Evolution Coevolution Comparative Genomics Algae
ISSN号	0735-9640
通讯作者	Qin, S (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China. sqin@yic.ac.cn
产权排序	[Cui, Hongli; Wang, Yipeng; Zhang, Hongyu; Wang, Yinchu; Qin, Song] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; [Cui, Hongli; Zhang, Hongyu; Wang, Yinchu] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
文献子类	Article
英文摘要	Biotin is a cofactor responsible for carbon dioxide transfer in several carboxylase enzymes, which play a significant role in various metabolic reactions such as fatty acid synthesis, branched chain amino acid catabolism, and gluconeogenesis. Biotin is also involved in citric acid cycle, which is the process of biochemical energy generation during aerobic respiration. Though the function of biotin in the growth of algae has been extensively investigated, little is known about the biosynthetic routes of biotin in the algal kingdom. In the present study, 44 biotin biosynthesis-related genes were identified from 14 eukaryotic photosynthetic algal genomes by BLASTP and TBLASN programs. A comprehensive analysis was performed to characterize distribution, phylogeny, structure domains, and coevolution patterns of those genes. Forty-four biotin biosynthesis-related enzymes (BBREs) were found to be distributed in three groups: 7-keto-8-aminopelargonic acid synthase, diaminopelargonic acid synthase/dethiobiotin synthetase, and biotin synthase. Structure domains were considerably conserved among the subfamilies of BBREs. The intramolecular coevolutionary sites are widely distributed in biotin synthase. The present study provides new insights into the origin and evolution of biotin biosynthetic pathways in eukaryotic photosynthetic algae. Furthermore, the characterization of biotin biosynthesis-related genes from algae will promote the identification and functional studies of BBREs.; Biotin is a cofactor responsible for carbon dioxide transfer in several carboxylase enzymes, which play a significant role in various metabolic reactions such as fatty acid synthesis, branched chain amino acid catabolism, and gluconeogenesis. Biotin is also involved in citric acid cycle, which is the process of biochemical energy generation during aerobic respiration. Though the function of biotin in the growth of algae has been extensively investigated, little is known about the biosynthetic routes of biotin in the algal kingdom. In the present study, 44 biotin biosynthesis-related genes were identified from 14 eukaryotic photosynthetic algal genomes by BLASTP and TBLASN programs. A comprehensive analysis was performed to characterize distribution, phylogeny, structure domains, and coevolution patterns of those genes. Forty-four biotin biosynthesis-related enzymes (BBREs) were found to be distributed in three groups: 7-keto-8-aminopelargonic acid synthase, diaminopelargonic acid synthase/dethiobiotin synthetase, and biotin synthase. Structure domains were considerably conserved among the subfamilies of BBREs. The intramolecular coevolutionary sites are widely distributed in biotin synthase. The present study provides new insights into the origin and evolution of biotin biosynthetic pathways in eukaryotic photosynthetic algae. Furthermore, the characterization of biotin biosynthesis-related genes from algae will promote the identification and functional studies of BBREs.
学科主题	Biochemistry & Molecular Biology ; Plant Sciences
URL标识	查看原文
WOS关键词	SACCHAROMYCES-CEREVISIAE ; CYANIDIOSCHYZON-MEROLAE ; ARABIDOPSIS-THALIANA ; CAROTENOID BIOSYNTHESIS ; SYNTHASE REACTION ; ESCHERICHIA-COLI ; GENE-TRANSFER ; RED ALGAE ; EVOLUTION ; PLANTS
WOS研究方向	Biochemistry & Molecular Biology ; Plant Sciences
语种	英语
WOS记录号	WOS:000301594300017
资助机构	National Natural Science Foundation of China[40876082]; Chinese Academy of Sciences; Outstanding Young Scholars Fellowship of Shandong Province (Molecular Phycology)[JQ200914]
公开日期	2012-06-13
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/5554]
专题	烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Cui, Hongli,Wang, Yipeng,Zhang, Hongyu,et al. Genome-Wide Analysis of Biotin Biosynthesis in Eukaryotic Photosynthetic Algae[J]. PLANT MOLECULAR BIOLOGY REPORTER,2012,30(2):421-432.
APA	Cui, Hongli,Wang, Yipeng,Zhang, Hongyu,Wang, Yinchu,&Qin, Song.(2012).Genome-Wide Analysis of Biotin Biosynthesis in Eukaryotic Photosynthetic Algae.PLANT MOLECULAR BIOLOGY REPORTER,30(2),421-432.
MLA	Cui, Hongli,et al."Genome-Wide Analysis of Biotin Biosynthesis in Eukaryotic Photosynthetic Algae".PLANT MOLECULAR BIOLOGY REPORTER 30.2(2012):421-432.