Homogentisic acid gamma-lactone suppresses the virulence factors of Pseudomonas aeruginosa by quenching its quorum sensing signal molecules

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	Homogentisic acid gamma-lactone suppresses the virulence factors of Pseudomonas aeruginosa by quenching its quorum sensing signal molecules
	Li, SH; Leung, PHM; Xu, XY; Wu, CH
刊名	CHINESE CHEMICAL LETTERS
	2018
卷号	29 期号:2 页码:313-316
通讯作者	polly.hm.leung@polyu.edu.hk
英文摘要	Bacterial quorum sensing (QS) molecules are involved in the coordination of certain behaviors such as biofilm formation, virulence and antibiotic resistance. QS molecules (autoinducers) and their corresponding receptors have been recognized as important therapeutic targets for drug -resistant infections and biofilm-associated infections (BAI). This study assessed the multiple biological effects of homogentisic acid gamma-lactone (HgAL), a furanone derivative. The anti -QS and anti-biofilm effects of HgAL against PAO1 strain were evaluated using CLSM, SEM, HPLC and other biochemical methods The results showed that HgAL could effectively inhibit the production of pyocyanin and extracellular matrix, as well as reduce the adherence ability and biofilm formation of Pseudomonas aeruginosa. Inhibition of virulence is attributed to the suppressive effect of HgAL on biosynthesis of 3-oxo-C-12-HSL and C-4-HSL (two kinds of QS signaling molecules in P. aeruginosa). Our results support HgAL as a potential agent for prevention of BAI in the healthcare settings. (C) 2017 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
学科主题	Chemistry
关键词[WOS]	Homogentisic acid gamma-lactone ; Quorum sensing ; Biofilm ; Pseudomonas aeruginosa ; Pyocyanin
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/17009]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
推荐引用方式 GB/T 7714	Li, SH,Leung, PHM,Xu, XY,et al. Homogentisic acid gamma-lactone suppresses the virulence factors of Pseudomonas aeruginosa by quenching its quorum sensing signal molecules[J]. CHINESE CHEMICAL LETTERS,2018,29(2):313-316.
APA	Li, SH,Leung, PHM,Xu, XY,&Wu, CH.(2018).Homogentisic acid gamma-lactone suppresses the virulence factors of Pseudomonas aeruginosa by quenching its quorum sensing signal molecules.CHINESE CHEMICAL LETTERS,29(2),313-316.
MLA	Li, SH,et al."Homogentisic acid gamma-lactone suppresses the virulence factors of Pseudomonas aeruginosa by quenching its quorum sensing signal molecules".CHINESE CHEMICAL LETTERS 29.2(2018):313-316.