The semi-synthesis, biological evaluation and docking analysis of the oxime, hydrazine and hydrazide derivatives of platensimycin

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	The semi-synthesis, biological evaluation and docking analysis of the oxime, hydrazine and hydrazide derivatives of platensimycin
	Huang, Y; Deng, YC; Kang, DD; Shi, J; Zhou, WQ; Sun, AJ; Ju, JH; Zhu, XC; Shen, B; Duan, YW
刊名	MEDCHEMCOMM
	2018
卷号	9 期号:5 页码:789-794
通讯作者	shenb@scripps.edu ; ywduan66@yahoo.com ; jonghuang@csu.edu.cn
英文摘要	A dozen oxime, hydrazine and hydrazide derivatives of platensimycin (PTM) analogues were synthesized, some of which showed strong antibacterial activities and were shown to be stable under the bioassay conditions. Docking analysis revealed that they have certain new interactions with beta-ketoacyl-[acyl carrier protein] synthase II (FabF), suggesting that Schiff base formation on its terpene scaffold is an effective strategy to diversify PTM structure.
学科主题	Biochemistry & Molecular Biology; Pharmacology & Pharmacy
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/16958]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
推荐引用方式 GB/T 7714	Huang, Y,Deng, YC,Kang, DD,et al. The semi-synthesis, biological evaluation and docking analysis of the oxime, hydrazine and hydrazide derivatives of platensimycin[J]. MEDCHEMCOMM,2018,9(5):789-794.
APA	Huang, Y.,Deng, YC.,Kang, DD.,Shi, J.,Zhou, WQ.,...&Duan, YW.(2018).The semi-synthesis, biological evaluation and docking analysis of the oxime, hydrazine and hydrazide derivatives of platensimycin.MEDCHEMCOMM,9(5),789-794.
MLA	Huang, Y,et al."The semi-synthesis, biological evaluation and docking analysis of the oxime, hydrazine and hydrazide derivatives of platensimycin".MEDCHEMCOMM 9.5(2018):789-794.