Highly Selective and Repeatable Surface-Enhanced Resonance Raman Scattering Detection for Epinephrine in Serum Based on Interface Self-Assembled 2D Nanoparticles Arrays

doi:10.1021/acsami.6b15205

CORC > 合肥物质科学研究院 > 中国科学院合肥物质科学研究院 > 中科院合肥智能机械研究所

	Highly Selective and Repeatable Surface-Enhanced Resonance Raman Scattering Detection for Epinephrine in Serum Based on Interface Self-Assembled 2D Nanoparticles Arrays
	Zhou, Binbin 1,2; Li, Xiaoyun 1,2; Tang, Xianghu 1,2; Li, Pan 1,2; Yang, Liangbao 1,2; Liu, Jinhuai 1,2
刊名	ACS APPLIED MATERIALS & INTERFACES
	2017-03-01
卷号	9 期号:8 页码:7772-7779
关键词	Interface Self-assemble Serrs Epinephrine Serum
DOI	10.1021/acsami.6b15205
文献子类	Article
英文摘要	Target analyte detection in complex systems with high selectivity and repeatability is crucial to analytical technology and science. Here we present a two-dimensional (2D) surface-enhanced resonance Raman scattering (SERRS) platform, which takes advantages of the high selectivity of the SERRS sensor as well as the sensitivity and reproducibility of the interfacial SERS platform, for detecting trace epinephrine (EP) in the serum. To realize sensitive and selective detection of EP in a complex system, Au NPs are modified with ccEgnitriloacetic acid and Fe(NO3)(3) to form the Au NP-(Fe-NTA) sensor, and as a consequence, EP can be rapidly captured by the sensor on the surface of Au NPs and then delivered at the cyclohexane/water interface. More importantly, we synthesized the extremely stable Au NPs (PVP-stabilized Au NPs), where the presence of PVP prevents aggregation of Au NPs during the self-assembly process and then makes a more uniform distribution of Au NPs with analytes at the cyclohexane/water interface, approximately 2 nm interparticle distance between the Au NPs, which has been proved by synchrotron radiation grazing incidence small-angle X-ray scattering (SR-GISAXS) experiments. The self assembly method not only effectively avoids the aggregation of Au NPs and decreases the influence of the background signal but also can capture and enrich EP molecules in the cyclohexane/water interface, realizing the sensitive and selective detection of EP in complex serum sample. This strategy overcomes the difficulty of bringing nanostructures together to form efficient interparticle distance with simple fabrication and maximum uniformity and also provides a powerful nanosensor for tracing amounts of analyte molecules in a complex system with the advantages of capturing and enriching of target molecules in the liquid/liquid interface during the self-assembly process. Our SERRS platform opens vast possibilities for repeatability, sensitivity, and selectivity detection of targets in various complex fields.
WOS关键词	LIQUID-LIQUID INTERFACES ; ASCORBIC-ACID ; DOPAMINE ; SPECTROSCOPY ; SENSITIVITY ; MONOLAYER ; SUBSTRATE ; ELECTRODE ; SIZE ; DNA
WOS研究方向	Science & Technology - Other Topics ; Materials Science
语种	英语
WOS记录号	WOS:000395494200124
资助机构	National Science Foundation of China(21571180 ; National Science Foundation of China(21571180 ; National Science Foundation of China(21571180 ; National Science Foundation of China(21571180 ; Special Financial Grant from the China Postdoctoral Science Foundation(2016T90590) ; Special Financial Grant from the China Postdoctoral Science Foundation(2016T90590) ; Special Financial Grant from the China Postdoctoral Science Foundation(2016T90590) ; Special Financial Grant from the China Postdoctoral Science Foundation(2016T90590) ; China Postdoctoral Science Foundation(2015M571950) ; China Postdoctoral Science Foundation(2015M571950) ; China Postdoctoral Science Foundation(2015M571950) ; China Postdoctoral Science Foundation(2015M571950) ; Anhui Natural Science Foundation(1508085MB26) ; Anhui Natural Science Foundation(1508085MB26) ; Anhui Natural Science Foundation(1508085MB26) ; Anhui Natural Science Foundation(1508085MB26) ; Open Project of State Key Laboratory of Physical Chemistry(201405) ; Open Project of State Key Laboratory of Physical Chemistry(201405) ; Open Project of State Key Laboratory of Physical Chemistry(201405) ; Open Project of State Key Laboratory of Physical Chemistry(201405) ; 21505138) ; 21505138) ; 21505138) ; 21505138) ; National Science Foundation of China(21571180 ; National Science Foundation of China(21571180 ; National Science Foundation of China(21571180 ; National Science Foundation of China(21571180 ; Special Financial Grant from the China Postdoctoral Science Foundation(2016T90590) ; Special Financial Grant from the China Postdoctoral Science Foundation(2016T90590) ; Special Financial Grant from the China Postdoctoral Science Foundation(2016T90590) ; Special Financial Grant from the China Postdoctoral Science Foundation(2016T90590) ; China Postdoctoral Science Foundation(2015M571950) ; China Postdoctoral Science Foundation(2015M571950) ; China Postdoctoral Science Foundation(2015M571950) ; China Postdoctoral Science Foundation(2015M571950) ; Anhui Natural Science Foundation(1508085MB26) ; Anhui Natural Science Foundation(1508085MB26) ; Anhui Natural Science Foundation(1508085MB26) ; Anhui Natural Science Foundation(1508085MB26) ; Open Project of State Key Laboratory of Physical Chemistry(201405) ; Open Project of State Key Laboratory of Physical Chemistry(201405) ; Open Project of State Key Laboratory of Physical Chemistry(201405) ; Open Project of State Key Laboratory of Physical Chemistry(201405) ; 21505138) ; 21505138) ; 21505138) ; 21505138)
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/31790]
专题	合肥物质科学研究院_中科院合肥智能机械研究所
作者单位	1.Chinese Acad Sci, Inst Intelligent Machines, Hefei, Anhui, Peoples R China 2.Univ Sci & Technol China, Dept Chem, Hefei, Anhui, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Appl, Shanghai Synchrotron Radiat Fac, Shanghai, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Zhou, Binbin,Li, Xiaoyun,Tang, Xianghu,et al. Highly Selective and Repeatable Surface-Enhanced Resonance Raman Scattering Detection for Epinephrine in Serum Based on Interface Self-Assembled 2D Nanoparticles Arrays[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(8):7772-7779.
APA	Zhou, Binbin,Li, Xiaoyun,Tang, Xianghu,Li, Pan,Yang, Liangbao,&Liu, Jinhuai.(2017).Highly Selective and Repeatable Surface-Enhanced Resonance Raman Scattering Detection for Epinephrine in Serum Based on Interface Self-Assembled 2D Nanoparticles Arrays.ACS APPLIED MATERIALS & INTERFACES,9(8),7772-7779.
MLA	Zhou, Binbin,et al."Highly Selective and Repeatable Surface-Enhanced Resonance Raman Scattering Detection for Epinephrine in Serum Based on Interface Self-Assembled 2D Nanoparticles Arrays".ACS APPLIED MATERIALS & INTERFACES 9.8(2017):7772-7779.