Designing of ordered two-dimensional gold nanoparticles film for cocaine detection in human urine using surface-enhanced Raman spectroscopy

doi:10.1016/j.talanta.2016.10.101

CORC > 合肥物质科学研究院 > 中国科学院合肥物质科学研究院 > 中科院合肥智能机械研究所

	Designing of ordered two-dimensional gold nanoparticles film for cocaine detection in human urine using surface-enhanced Raman spectroscopy
	Meng, Juan 1; Tang, Xianghu 1; Zhou, Binbin 1; Xie, Qiwen 2; Yang, Liangbao 1
刊名	TALANTA
	2017-03-01
卷号	164 页码:693-699
关键词	Surface-enhanced Raman Spectroscopy Cocaine Urine Liquid-liquid Microextraction Self-assembly
DOI	10.1016/j.talanta.2016.10.101
文献子类	Article
英文摘要	A novel and rapid method to detect cocaine in human urine has been developed by using self-assembly ordered two dimensional (2D) gold nanoparticles (GNPs) film as surface-enhanced Raman spectroscopy (SERS) substrates. In order to obtain high sensitivity, uniformity, and reproducibility of SERS platform, quasi spherical, uniform GNPs were firstly synthesis using seed growth method, in which the GNPs have been functionalized with CTAB to form orderly close-packed GNPs film as SERS substrate. Importantly, the high-performance GNPs on solid substrates can produce a high yield of sub-10-nm gaps which can generate gigantic signals enhancement for analytes adsorbed GNPs surface. In view of the complex component of human urine, we develop a rapid and efficient pretreatment strategy for separation and purification of cocaine by using hexane extraction in real human urine samples within 3 min. With the advantages of better extraction rates (> 75%) examined by ultraperformance liquid chromatography (UPLC) and the excellent signal-to-noise ratio detected by SERS, our pretreatment procedure can efficiently lower the interference of complex biological components in urine. To reach on-spot analyzer, a handheld Raman spectrometer was used for feasible SERS detection of cocaine in real human urine. The favorable results demonstrated our pretreatment strategy combined with SERS platform will be a great prospective method toward rapid, reliable, and on-spot cocaine detection for public safety.
WOS关键词	CHROMATOGRAPHIC ANALYSIS ; MASS-SPECTROMETRY ; SERS SUBSTRATE ; HUMAN-PLASMA ; IDENTIFICATION ; DRUGS ; PERFORMANCE ; SCATTERING ; BENZOYLECGONINE ; SUPERSTRUCTURE
WOS研究方向	Chemistry
语种	英语
WOS记录号	WOS:000393244400096
资助机构	National Science Foundation of China(21571180 ; National Science Foundation of China(21571180 ; National Science Foundation of China(21571180 ; National Science Foundation of China(21571180 ; National Science Foundation of China(21571180 ; National Science Foundation of China(21571180 ; National Science Foundation of China(21571180 ; National Science Foundation of China(21571180 ; China Postdoctoral Science Foundation(2016T90590 ; China Postdoctoral Science Foundation(2016T90590 ; China Postdoctoral Science Foundation(2016T90590 ; China Postdoctoral Science Foundation(2016T90590 ; China Postdoctoral Science Foundation(2016T90590 ; China Postdoctoral Science Foundation(2016T90590 ; China Postdoctoral Science Foundation(2016T90590 ; China Postdoctoral Science Foundation(2016T90590 ; 21505138) ; 21505138) ; 21505138) ; 21505138) ; 21505138) ; 21505138) ; 21505138) ; 21505138) ; 2015M571950) ; 2015M571950) ; 2015M571950) ; 2015M571950) ; 2015M571950) ; 2015M571950) ; 2015M571950) ; 2015M571950) ; National Science Foundation of China(21571180 ; National Science Foundation of China(21571180 ; National Science Foundation of China(21571180 ; National Science Foundation of China(21571180 ; National Science Foundation of China(21571180 ; National Science Foundation of China(21571180 ; National Science Foundation of China(21571180 ; National Science Foundation of China(21571180 ; China Postdoctoral Science Foundation(2016T90590 ; China Postdoctoral Science Foundation(2016T90590 ; China Postdoctoral Science Foundation(2016T90590 ; China Postdoctoral Science Foundation(2016T90590 ; China Postdoctoral Science Foundation(2016T90590 ; China Postdoctoral Science Foundation(2016T90590 ; China Postdoctoral Science Foundation(2016T90590 ; China Postdoctoral Science Foundation(2016T90590 ; 21505138) ; 21505138) ; 21505138) ; 21505138) ; 21505138) ; 21505138) ; 21505138) ; 21505138) ; 2015M571950) ; 2015M571950) ; 2015M571950) ; 2015M571950) ; 2015M571950) ; 2015M571950) ; 2015M571950) ; 2015M571950)
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/31681]
专题	合肥物质科学研究院_中科院合肥智能机械研究所
作者单位	1.Chinese Acad Sci, Inst Intelligent Machines, Hefei 230031, Peoples R China 2.Anhui Publ Secur Dept, Inst Forens, Hefei 230061, Peoples R China
推荐引用方式 GB/T 7714	Meng, Juan,Tang, Xianghu,Zhou, Binbin,et al. Designing of ordered two-dimensional gold nanoparticles film for cocaine detection in human urine using surface-enhanced Raman spectroscopy[J]. TALANTA,2017,164:693-699.
APA	Meng, Juan,Tang, Xianghu,Zhou, Binbin,Xie, Qiwen,&Yang, Liangbao.(2017).Designing of ordered two-dimensional gold nanoparticles film for cocaine detection in human urine using surface-enhanced Raman spectroscopy.TALANTA,164,693-699.
MLA	Meng, Juan,et al."Designing of ordered two-dimensional gold nanoparticles film for cocaine detection in human urine using surface-enhanced Raman spectroscopy".TALANTA 164(2017):693-699.