Total synthesis of mambalgin-1/2/3 by two-segment hydrazide-based native chemical ligation

doi:10.1002/psc.2868

CORC > 合肥物质科学研究院 > 中国科学院合肥物质科学研究院 > 中科院强磁场科学中心

	Total synthesis of mambalgin-1/2/3 by two-segment hydrazide-based native chemical ligation
	Lan, Huan 1,2; Wu, Kun 3,4; Zheng, Yong 5; Pan, Man 2; Huang, Yi-Chao 1; Gao, Shuai 1,2; Zheng, Qing-Yun 1; Zheng, Ji-Shen 5; Li, Yi-Ming 6,7; Xiao, Bailong 3,4
刊名	JOURNAL OF PEPTIDE SCIENCE
	2016-05-01
卷号	22 期号:5 页码:320-326
关键词	Mambalgins Toxin Native Chemical Ligation Peptide Hydrazides Acid-sensing Ion Channels
DOI	10.1002/psc.2868
文献子类	Article
英文摘要	Mambalgins are a class of 57-residue polypeptide toxins isolated from the venom of the African mamba. They exhibit potent analgesic effects by inhibiting the acid-sensing ion channels. Classified asmembers of the family of three-finger toxins, mambalgins contain four pairs of disulfide bridges that help to stabilize the three-finger scaffold. Here, we report the chemical synthesis of functional mambalgin-1/2/3 by using one-step two-segment hydrazide-based native chemical ligation. The two-segment ligation approach reported here may enable efficient production of mambalgin toxins. These synthetic mambalgins are useful compounds for development of diagnostic or therapeutic reagents. Copyright (C) 2016 European Peptide Society and John Wiley & Sons, Ltd.
WOS关键词	SENSING ION CHANNELS ; PAIN-RELIEVING PEPTIDE ; SOLID-PHASE SYNTHESIS ; THERAPEUTIC TARGETS ; MAMBA VENOM ; PROTEINS ; DISEASES ; ASICS ; 1A
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
WOS记录号	WOS:000378350700010
资助机构	National Science Foundation China(21532004 ; National Science Foundation China(21532004 ; National Science Foundation China(21532004 ; National Science Foundation China(21532004 ; National Science Foundation China(21532004 ; National Science Foundation China(21532004 ; National Science Foundation China(21532004 ; National Science Foundation China(21532004 ; Ministry of Science and Technology of China(2013CB932800) ; Ministry of Science and Technology of China(2013CB932800) ; Ministry of Science and Technology of China(2013CB932800) ; Ministry of Science and Technology of China(2013CB932800) ; Ministry of Science and Technology of China(2013CB932800) ; Ministry of Science and Technology of China(2013CB932800) ; Ministry of Science and Technology of China(2013CB932800) ; Ministry of Science and Technology of China(2013CB932800) ; Specialized Research Fund for the Doctoral Program of Higher Education(20120002130004) ; Specialized Research Fund for the Doctoral Program of Higher Education(20120002130004) ; Specialized Research Fund for the Doctoral Program of Higher Education(20120002130004) ; Specialized Research Fund for the Doctoral Program of Higher Education(20120002130004) ; Specialized Research Fund for the Doctoral Program of Higher Education(20120002130004) ; Specialized Research Fund for the Doctoral Program of Higher Education(20120002130004) ; Specialized Research Fund for the Doctoral Program of Higher Education(20120002130004) ; Specialized Research Fund for the Doctoral Program of Higher Education(20120002130004) ; Anhui Provincial Natural Science Foundation(1508085QB30) ; Anhui Provincial Natural Science Foundation(1508085QB30) ; Anhui Provincial Natural Science Foundation(1508085QB30) ; Anhui Provincial Natural Science Foundation(1508085QB30) ; Anhui Provincial Natural Science Foundation(1508085QB30) ; Anhui Provincial Natural Science Foundation(1508085QB30) ; Anhui Provincial Natural Science Foundation(1508085QB30) ; Anhui Provincial Natural Science Foundation(1508085QB30) ; State Key Laboratory of Medicinal Chemical Biology ; State Key Laboratory of Medicinal Chemical Biology ; State Key Laboratory of Medicinal Chemical Biology ; State Key Laboratory of Medicinal Chemical Biology ; State Key Laboratory of Medicinal Chemical Biology ; State Key Laboratory of Medicinal Chemical Biology ; State Key Laboratory of Medicinal Chemical Biology ; State Key Laboratory of Medicinal Chemical Biology ; 21225207 ; 21225207 ; 21225207 ; 21225207 ; 21225207 ; 21225207 ; 21225207 ; 21225207 ; 21402206 ; 21402206 ; 21402206 ; 21402206 ; 21402206 ; 21402206 ; 21402206 ; 21402206 ; 21572043) ; 21572043) ; 21572043) ; 21572043) ; 21572043) ; 21572043) ; 21572043) ; 21572043) ; National Science Foundation China(21532004 ; National Science Foundation China(21532004 ; National Science Foundation China(21532004 ; National Science Foundation China(21532004 ; National Science Foundation China(21532004 ; National Science Foundation China(21532004 ; National Science Foundation China(21532004 ; National Science Foundation China(21532004 ; Ministry of Science and Technology of China(2013CB932800) ; Ministry of Science and Technology of China(2013CB932800) ; Ministry of Science and Technology of China(2013CB932800) ; Ministry of Science and Technology of China(2013CB932800) ; Ministry of Science and Technology of China(2013CB932800) ; Ministry of Science and Technology of China(2013CB932800) ; Ministry of Science and Technology of China(2013CB932800) ; Ministry of Science and Technology of China(2013CB932800) ; Specialized Research Fund for the Doctoral Program of Higher Education(20120002130004) ; Specialized Research Fund for the Doctoral Program of Higher Education(20120002130004) ; Specialized Research Fund for the Doctoral Program of Higher Education(20120002130004) ; Specialized Research Fund for the Doctoral Program of Higher Education(20120002130004) ; Specialized Research Fund for the Doctoral Program of Higher Education(20120002130004) ; Specialized Research Fund for the Doctoral Program of Higher Education(20120002130004) ; Specialized Research Fund for the Doctoral Program of Higher Education(20120002130004) ; Specialized Research Fund for the Doctoral Program of Higher Education(20120002130004) ; Anhui Provincial Natural Science Foundation(1508085QB30) ; Anhui Provincial Natural Science Foundation(1508085QB30) ; Anhui Provincial Natural Science Foundation(1508085QB30) ; Anhui Provincial Natural Science Foundation(1508085QB30) ; Anhui Provincial Natural Science Foundation(1508085QB30) ; Anhui Provincial Natural Science Foundation(1508085QB30) ; Anhui Provincial Natural Science Foundation(1508085QB30) ; Anhui Provincial Natural Science Foundation(1508085QB30) ; State Key Laboratory of Medicinal Chemical Biology ; State Key Laboratory of Medicinal Chemical Biology ; State Key Laboratory of Medicinal Chemical Biology ; State Key Laboratory of Medicinal Chemical Biology ; State Key Laboratory of Medicinal Chemical Biology ; State Key Laboratory of Medicinal Chemical Biology ; State Key Laboratory of Medicinal Chemical Biology ; State Key Laboratory of Medicinal Chemical Biology ; 21225207 ; 21225207 ; 21225207 ; 21225207 ; 21225207 ; 21225207 ; 21225207 ; 21225207 ; 21402206 ; 21402206 ; 21402206 ; 21402206 ; 21402206 ; 21402206 ; 21402206 ; 21402206 ; 21572043) ; 21572043) ; 21572043) ; 21572043) ; 21572043) ; 21572043) ; 21572043) ; 21572043)
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/22460]
专题	合肥物质科学研究院_中科院强磁场科学中心
作者单位	1.Tsinghua Univ, Tsinghua Peking Ctr Life Sci, Beijing 100084, Peoples R China 2.Tsinghua Univ, Dept Chem, Minist Educ, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing 100084, Peoples R China 3.Tsinghua Univ, Sch Pharmaceut Sci, IDG McGovern Inst Brain Res, Beijing 100084, Peoples R China 4.Tsinghua Univ, Sch Pharmaceut Sci, Beijing 100084, Peoples R China 5.Chinese Acad Sci, High Field Magnet Lab, Hefei 230031, Peoples R China 6.Hefei Univ Technol, Sch Med Engn, Hefei 230009, Peoples R China 7.Nankai Univ, State Key Lab Med Chem Biol, Nankai, Peoples R China
推荐引用方式 GB/T 7714	Lan, Huan,Wu, Kun,Zheng, Yong,et al. Total synthesis of mambalgin-1/2/3 by two-segment hydrazide-based native chemical ligation[J]. JOURNAL OF PEPTIDE SCIENCE,2016,22(5):320-326.
APA	Lan, Huan.,Wu, Kun.,Zheng, Yong.,Pan, Man.,Huang, Yi-Chao.,...&Liu, Lei.(2016).Total synthesis of mambalgin-1/2/3 by two-segment hydrazide-based native chemical ligation.JOURNAL OF PEPTIDE SCIENCE,22(5),320-326.
MLA	Lan, Huan,et al."Total synthesis of mambalgin-1/2/3 by two-segment hydrazide-based native chemical ligation".JOURNAL OF PEPTIDE SCIENCE 22.5(2016):320-326.