Peptide-Assisted Enhancement of Inhibitory Effects of Small Molecular Inhibitors for Kinases

doi:10.1246/bcsj.20150414

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	Peptide-Assisted Enhancement of Inhibitory Effects of Small Molecular Inhibitors for Kinases
	Wang, Wei 1,4; Hirano, Yoshinori 2; Uzawa, Takanori 1,3; Taiji, Makoto 2; Ito, Yoshihiro 1,3
刊名	BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN
	2016-04-15
卷号	89 期号:4 页码:444-446
DOI	10.1246/bcsj.20150414
文献子类	Article
英文摘要	Conjugation of small molecular inhibitor with a site recognition peptide would generate highly potent peptide drug conjugate inhibitors of protein kinases. A peptide selected by ribosome display with a tRNA carrying an inhibitor conjugated amino acid exhibited up to 10- to 100-fold higher inhibitory effects towards different kinases than solely the inhibitor.
WOS关键词	IN-VITRO SELECTION ; APTAMER ; RNA ; RECOGNITION ; LIBRARY ; DESIGN
WOS研究方向	Chemistry
语种	英语
WOS记录号	WOS:000374275900005
资助机构	Japan Society for the Promotion of Science KAKENHI(15H01810 ; Japan Society for the Promotion of Science KAKENHI(15H01810 ; Japan Society for the Promotion of Science KAKENHI(15H01810 ; Japan Society for the Promotion of Science KAKENHI(15H01810 ; Japan Society for the Promotion of Science KAKENHI(15H01810 ; Japan Society for the Promotion of Science KAKENHI(15H01810 ; Japan Society for the Promotion of Science KAKENHI(15H01810 ; Japan Society for the Promotion of Science KAKENHI(15H01810 ; 22220009) ; 22220009) ; 22220009) ; 22220009) ; 22220009) ; 22220009) ; 22220009) ; 22220009) ; Japan Society for the Promotion of Science KAKENHI(15H01810 ; Japan Society for the Promotion of Science KAKENHI(15H01810 ; Japan Society for the Promotion of Science KAKENHI(15H01810 ; Japan Society for the Promotion of Science KAKENHI(15H01810 ; Japan Society for the Promotion of Science KAKENHI(15H01810 ; Japan Society for the Promotion of Science KAKENHI(15H01810 ; Japan Society for the Promotion of Science KAKENHI(15H01810 ; Japan Society for the Promotion of Science KAKENHI(15H01810 ; 22220009) ; 22220009) ; 22220009) ; 22220009) ; 22220009) ; 22220009) ; 22220009) ; 22220009)
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/22360]
专题	合肥物质科学研究院_中科院强磁场科学中心
作者单位	1.RIKEN, Nano Med Engn Lab, 2-1 Hirosawa, Wako, Saitama 3510198, Japan 2.RIKEN, Quantitat Biol Ctr, Lab Computat Mol Design, Computat Biol Res Core,Chou Ku, 1-6-5 Minatojima Minamimachi, Kobe, Hyogo 6500047, Japan 3.RIKEN, Ctr Emergent Matter Sci, Emergent Bioengn Mat Res Team, 2-1 Hirosawa, Wako, Saitama 3510198, Japan 4.Chinese Acad Sci, High Field Magnet Lab, Hefei 230031, Anhui, Peoples R China
推荐引用方式 GB/T 7714	Wang, Wei,Hirano, Yoshinori,Uzawa, Takanori,et al. Peptide-Assisted Enhancement of Inhibitory Effects of Small Molecular Inhibitors for Kinases[J]. BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN,2016,89(4):444-446.
APA	Wang, Wei,Hirano, Yoshinori,Uzawa, Takanori,Taiji, Makoto,&Ito, Yoshihiro.(2016).Peptide-Assisted Enhancement of Inhibitory Effects of Small Molecular Inhibitors for Kinases.BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN,89(4),444-446.
MLA	Wang, Wei,et al."Peptide-Assisted Enhancement of Inhibitory Effects of Small Molecular Inhibitors for Kinases".BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN 89.4(2016):444-446.