Serum Monounsaturated Triacylglycerol Predicts Steatohepatitis in Patients with Non-alcoholic Fatty Liver Disease and Chronic Hepatitis B

	Serum Monounsaturated Triacylglycerol Predicts Steatohepatitis in Patients with Non-alcoholic Fatty Liver Disease and Chronic Hepatitis B
	Fan, Jian-gao 1; Hu, Chun-xiu 3; Sun, Wan-lu 1; Pan, Qin 1; Shen, Feng 1; Yang, Zhen 2; Yang, Rui-xu 1; Su, Qing 2; Xu, Guo-wang 3
刊名	SCIENTIFIC REPORTS
	2017-09-05
卷号	7
英文摘要	Chronic liver disease is associated with lipid metabolic disruption. We carried out a study to determine serum lipidomic features of patients with non-alcoholic fatty liver disease (NAFLD) and active chronic hepatitis B (CHB) and explored the biomarkers for non-alcoholic steatohepatitis (NASH). Serum lipidomic profiles of healthy controls (n = 23) and of biopsy-proven NAFLD (n = 42), CHB with NAFLD (n = 22) and without NAFLD (n = 17) were analyzed by ultra-performance liquid chromatography-tandem mass spectrometry. There were distinct serum lipidome between groups of NAFLD and CHB without NAFLD. Most of the neutral lipids and ceramide were elevated in the NAFLD group but were decreased in the CHB without NAFLD group. Plasmalogens were decreased in both groups. Triacylglycerols (TAGs) with lower carbon numbers and double bonds were increased in subjects with NASH. Serum monounsaturated TAG was a significant predictor of NASH (OR = 3.215; 95% CI 1.663-6.331) and positively correlated with histological activity (r = 0.501; P < 0.001). It showed good predictability for NASH in the NAFLD group [area under the receiver operating characteristic curves (AUROC) = 0.831] and was validated in the CHB group (AUROC = 0.833); this characteristic was superior to that of cytokeratin-18 and alanine transaminase. The increase in monounsaturated TAG might be a specific marker for NASH in both NAFLD and CHB patients.
WOS标题词	Science & Technology
类目[WOS]	Multidisciplinary Sciences
研究领域[WOS]	Science & Technology - Other Topics
关键词[WOS]	CONTROLLED ATTENUATION PARAMETER ; INSULIN-RESISTANCE ; METABOLIC SYNDROME ; VIRUS INFECTION ; STEATOSIS ; FIBROSIS ; PLASMALOGENS ; PERFORMANCE ; PROGRESSION ; BIOMARKERS
收录类别	SCI
语种	英语
WOS记录号	WOS:000409309300105
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/149913]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Dept Gastroenterol,Ctr Fatty Liver, Shanghai 200092, Peoples R China 2.Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Dept Endocrinol, Shanghai 200092, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China
推荐引用方式 GB/T 7714	Fan, Jian-gao,Hu, Chun-xiu,Sun, Wan-lu,et al. Serum Monounsaturated Triacylglycerol Predicts Steatohepatitis in Patients with Non-alcoholic Fatty Liver Disease and Chronic Hepatitis B[J]. SCIENTIFIC REPORTS,2017,7.
APA	Fan, Jian-gao.,Hu, Chun-xiu.,Sun, Wan-lu.,Pan, Qin.,Shen, Feng.,...&Xu, Guo-wang.(2017).Serum Monounsaturated Triacylglycerol Predicts Steatohepatitis in Patients with Non-alcoholic Fatty Liver Disease and Chronic Hepatitis B.SCIENTIFIC REPORTS,7.
MLA	Fan, Jian-gao,et al."Serum Monounsaturated Triacylglycerol Predicts Steatohepatitis in Patients with Non-alcoholic Fatty Liver Disease and Chronic Hepatitis B".SCIENTIFIC REPORTS 7(2017).