Generic synthesis and versatile applications of molecularly organic-inorganic hybrid mesoporous organosilica nanoparticles with asymmetric Janus topologies and structures

CORC > 上海光学精密机械研究所 > 中国科学院上海光学精密机械研究所 > 中科院强激光材料重点实验室

	Generic synthesis and versatile applications of molecularly organic-inorganic hybrid mesoporous organosilica nanoparticles with asymmetric Janus topologies and structures
	Zhang, Jiamin; Tao, Guiju; Bai, Zhengyuan; Zhang, Long; Chen, Yu; Yao, Heliang; Wu, Meiying; Huang, Ping; Yu, Luodan; Dai, Chen
刊名	Nano Res.
	2017
卷号	10 期号:11 页码:3790
通讯作者	chenyu@mail.sic.ac.cn ; lzhang@siom.ac.cn
英文摘要	Precise control over the morphology, nanostructure, composition, and particle size of molecularly organic-inorganic hybrid mesoporous organosilica nanoparticles (MONs) still remains a major challenge, which severely restricts their broad applications. In this work, an efficient bridged organic group-determined growth strategy has been proposed for the facile synthesis of highly dispersed and uniform MONs with multifarious Janus morphologies, nanostructures, organic-inorganic hybrid compositions, and particle sizes, which can be easily controlled simply by varying the bridged organic groups and the concentration of bis-silylated organosilica precursors used in the synthesis. In addition, the formation mechanism of Janus MONs determined by the bridged organic group has been discussed. Based on the specific structures, compositions, and asymmetric morphologies, all the synthesized Janus MONs with hollow structures (JHMONs) demonstrate excellent performances in nanomedicine as desirable drug carriers with high drug-loading efficiencies/capacities, pH-responsive drug releasing, and enhanced therapeutic efficiencies, as attractive contrastenhanced contrast agents for ultrasound imaging, and as excellent bilirubin adsorbents with noticeably high adsorption capacities and high blood compatibilities. The developed versatile synthetic strategy and the obtained JHMONs are extremely important in the development and applications of MONs, particularly in the areas of nanoscience and nanotechnology.
收录类别	SCI
资助信息	National Key Research and Development Program of China [2016YFA0203700]; Shanghai Natural Science Foundation [16ZR1440300]; National Natural Science Foundation of China [61275208, 51302293, 51672303]; Shanghai Rising-Star Program [14QA1404100]; Youth Innovation Promotion Association of the Chinese Academy of Sciences [2013169]; Development Fund for Shanghai Talents
WOS记录号	WOS:000413100400017
内容类型	期刊论文
源URL	[http://ir.siom.ac.cn/handle/181231/28086]
专题	上海光学精密机械研究所_中科院强激光材料重点实验室
作者单位	中国科学院上海光学精密机械研究所
推荐引用方式 GB/T 7714	Zhang, Jiamin,Tao, Guiju,Bai, Zhengyuan,et al. Generic synthesis and versatile applications of molecularly organic-inorganic hybrid mesoporous organosilica nanoparticles with asymmetric Janus topologies and structures[J]. Nano Res.,2017,10(11):3790.
APA	Zhang, Jiamin.,Tao, Guiju.,Bai, Zhengyuan.,Zhang, Long.,Chen, Yu.,...&Dai, Chen.(2017).Generic synthesis and versatile applications of molecularly organic-inorganic hybrid mesoporous organosilica nanoparticles with asymmetric Janus topologies and structures.Nano Res.,10(11),3790.
MLA	Zhang, Jiamin,et al."Generic synthesis and versatile applications of molecularly organic-inorganic hybrid mesoporous organosilica nanoparticles with asymmetric Janus topologies and structures".Nano Res. 10.11(2017):3790.