Multi-Residue Method for the Screening of Benzimidazole and Metabolite Residues in the Muscle and Liver of Sheep and Cattle Using HPLC/PDAD with DVB-NVP-SO3Na for Sample Treatment

doi:10.1007/s10337-016-3144-7

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	Multi-Residue Method for the Screening of Benzimidazole and Metabolite Residues in the Muscle and Liver of Sheep and Cattle Using HPLC/PDAD with DVB-NVP-SO3Na for Sample Treatment
	Xiong, L; Huang, LL; Shimo, SP; Li, WH; Yang, XL; Yan, P; Xiong, L (reprint author), Chinese Acad Agr Sci, Lanzhou Inst Husb & Pharmaceut Sci, 335 Jiangouyan St, Lanzhou, Gansu, Peoples R China.; Xiong, L (reprint author), Minist Agr, Lab Qual & Safety Risk Assessment Livestock Prod, 335 Jiangouyan St, Lanzhou, Gansu, Peoples R China.
刊名	CHROMATOGRAPHIA
	2016-10
卷号	79 期号:19-20 页码:1373-1380
关键词	Benzimidazole Metabolites Screening method HPLC/PDAD DVB-NVP-SO3Na
ISSN号	0009-5893
DOI	10.1007/s10337-016-3144-7
文献子类	Article
英文摘要	A high-performance liquid chromatography (HPLC) screening method with a photodiode array detector (PDAD) was established for the simultaneous determination of residues of 13 benzimidazoles (BZDs) and metabolites in sheep and cattle muscle and liver. Samples were extracted by ultrasonication in ethyl acetate and purified over DVB-NVP-SO3Na sorbent. Under the optimized conditions, good linearities were obtained for BZDs and metabolites with correlation coefficients (R-2) greater than 0.9911. The recoveries of the 13 BZDs and metabolites from spiked samples were 72.0-119.3 %, with intraday and interday relative standard deviations (RSDs) below 22.8 %. The limits of detection (LODs) and quantitation (LOQs) were 0.8-4.9 and 2.6-18.2 mu g kg(-1), respectively. The results clearly demonstrated that the developed approach enables reliable screening of 12 BZDs and metabolites except flubendazole (FLU) and could be used as a regulatory tool for the screening of BZD and metabolite residues in the muscle and liver of sheep and cattle.
学科主题	Biochemistry & Molecular Biology ; Chemistry
出版地	HEIDELBERG
项目编号	Chinese Academy of Agricultural Sciences [1610322014014]
语种	英语
WOS记录号	WOS:000387326400016
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/188703]
专题	第二临床医学院_期刊论文
通讯作者	Xiong, L (reprint author), Chinese Acad Agr Sci, Lanzhou Inst Husb & Pharmaceut Sci, 335 Jiangouyan St, Lanzhou, Gansu, Peoples R China.; Xiong, L (reprint author), Minist Agr, Lab Qual & Safety Risk Assessment Livestock Prod, 335 Jiangouyan St, Lanzhou, Gansu, Peoples R China.
推荐引用方式 GB/T 7714	Xiong, L,Huang, LL,Shimo, SP,et al. Multi-Residue Method for the Screening of Benzimidazole and Metabolite Residues in the Muscle and Liver of Sheep and Cattle Using HPLC/PDAD with DVB-NVP-SO3Na for Sample Treatment[J]. CHROMATOGRAPHIA,2016,79(19-20):1373-1380.
APA	Xiong, L.,Huang, LL.,Shimo, SP.,Li, WH.,Yang, XL.,...&Xiong, L .(2016).Multi-Residue Method for the Screening of Benzimidazole and Metabolite Residues in the Muscle and Liver of Sheep and Cattle Using HPLC/PDAD with DVB-NVP-SO3Na for Sample Treatment.CHROMATOGRAPHIA,79(19-20),1373-1380.
MLA	Xiong, L,et al."Multi-Residue Method for the Screening of Benzimidazole and Metabolite Residues in the Muscle and Liver of Sheep and Cattle Using HPLC/PDAD with DVB-NVP-SO3Na for Sample Treatment".CHROMATOGRAPHIA 79.19-20(2016):1373-1380.