3,4,5-Trimethoxycinnamic acid, one of the constituents of Polygalae Radix exerts anti-seizure effects by modulating GABAAergic systems in mice

doi:10.1016/j.jphs.2015.07.021

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	3,4,5-Trimethoxycinnamic acid, one of the constituents of Polygalae Radix exerts anti-seizure effects by modulating GABAAergic systems in mice
	Chen, CY; Wei, XD; Chen, CR; Chen, CR (reprint author), Fudan Univ, Shanghai Med Coll, Dept Pharmacol, Shanghai 200032, Peoples R China.
刊名	JOURNAL OF PHARMACOLOGICAL SCIENCES
	2016-05
卷号	131 期号:1 页码:1-5
关键词	TMCA Seizure GABA receptor Pentylenetetrazol Flumazenil
ISSN号	1347-8613
DOI	10.1016/j.jphs.2015.07.021
文献子类	Article
英文摘要	Polygalae Radix is an important medicinal plant that is widely used in most of Africa. 3,4,5-Trimethoxycinnamic acid (TMCA) is one of the constituents of Polygalae Radix. Until now, the mechanisms involved in the anti-seizure property of TMCA are still unclear. We examined the anti-seizure effect of TMCA. TMCA administered at doses of 5, 10 and 20 mg/kg and evaluated anti-seizure effects by maximal electroshock (MES) and pentylenetetrazol (PTZ) models in mice. TMCA administered at doses of 10 and 20 mg/kg significantly reduced the incidence of MES-induced tonic hindlimb extension (THE). TMCA significantly delayed the onset of myoclonic jerks (MJ), and decreased the seizure severity and mortality compared with the vehicle-treated animals in PTZ seizure model. TMCA 10 and 20 mg/kg treated groups also did not determined generalized clonic seizures (GCS). Pretreatment with a GABAA/benzodiazepine (BZ) receptor antagonist flumazenil blocked the antiseizure effects of TMCA. These data support the further investigation of TMCA as a GABAA/BZ receptor agonist for anti-seizure therapy. (C) 2015 The Authors. Production and hosting by Elsevier B. V. on behalf of Japanese Pharmacological Society. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
学科主题	Pharmacology & Pharmacy
出版地	KYOTO
资助项目	中央高校基本科研业务费专项资金
项目编号	Fundamental Research Funds for the Central Universities [lzujbky-2013-218]
语种	英语
WOS记录号	WOS:000377993400001
资助机构	LZU
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/178644]
专题	第一临床医学院_期刊论文
通讯作者	Chen, CR (reprint author), Fudan Univ, Shanghai Med Coll, Dept Pharmacol, Shanghai 200032, Peoples R China.
推荐引用方式 GB/T 7714	Chen, CY,Wei, XD,Chen, CR,et al. 3,4,5-Trimethoxycinnamic acid, one of the constituents of Polygalae Radix exerts anti-seizure effects by modulating GABAAergic systems in mice[J]. JOURNAL OF PHARMACOLOGICAL SCIENCES,2016,131(1):1-5.
APA	Chen, CY,Wei, XD,Chen, CR,&Chen, CR .(2016).3,4,5-Trimethoxycinnamic acid, one of the constituents of Polygalae Radix exerts anti-seizure effects by modulating GABAAergic systems in mice.JOURNAL OF PHARMACOLOGICAL SCIENCES,131(1),1-5.
MLA	Chen, CY,et al."3,4,5-Trimethoxycinnamic acid, one of the constituents of Polygalae Radix exerts anti-seizure effects by modulating GABAAergic systems in mice".JOURNAL OF PHARMACOLOGICAL SCIENCES 131.1(2016):1-5.