Clinicopathological significance of fascin-1 expression in patients with non-small cell lung cancer

doi:10.2147/OTT.S84308

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	Clinicopathological significance of fascin-1 expression in patients with non-small cell lung cancer
	Ling, XL; Zhang, T; Hou, XM; Zhao, D; Zhao, D (reprint author), Lanzhou Univ, Dept Oncol, Hosp 1, Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China.
刊名	ONCOTARGETS AND THERAPY
	2015
卷号	8 页码:1589-1595
关键词	fascin-1 NSCLC biomarker prognosis
ISSN号	1178-6930
DOI	10.2147/OTT.S84308
文献子类	Article
英文摘要	Purpose: Fascin-1 promotes the formation of filopodia, lamellipodia, and microspikes of cell membrane after its cross-linking with F-actin, thereby enhancing the cell movement and metastasis and invasion of tumor cells. This study explored the fascin-1 protein's expression in non-small cell lung cancer (NSCLC) tissues and its relationship with clinical pathology and prognostic indicators. Methods: Immunohistochemical analysis was used to determine the expression of fascin-1 in NSCLC tissues. We used quantitative real-time polymerase chain reaction and western blot analysis to further verify the results. The fascin-1 expression and statistical method for clinical pathological parameters are examined by chi(2). Kaplan-Meier method is used for survival analysis. Cox's Proportional Hazard Model was used to conduct a combined-effect analysis for each covariate. Results: In 73 of the 128 cases, NSCLC cancer tissues (57.0%) were found with high expression of fascin-1, which was significantly higher than the adjacent tissues (35/128, 27.3%). The results suggested that the high expression of fascin-1 was significantly correlated with lymph node metastasis (P=0.022) and TNM stage (P=0.042). The high fascin-1 expression patients survived shorter than those NSCLC patients with low fascin-1 expression (P<0.05). Univariate analysis revealed that lymph node metastasis, TNM stage, and fascin-1 expression status were correlated with the overall survival. Similarly, lymph node metastasis, TNM stage, and fascin-1 expression status were significantly associated with the overall survival in multivariate analyses by using the Cox regression model. Conclusion: The fascin-1 protein may be a useful prognostic indicator and hopeful new target for NSCLC patients.
学科主题	Biotechnology & Applied Microbiology ; Oncology
出版地	ALBANY
资助项目	甘肃省技术研究与开发专项计划 ; 甘肃省科技支撑计划
项目编号	Science and Technology Project in Gansu Province of China [090NKCA126] ; Project of Special technology research and development program in Gansu Province of China [1004TCYA023]
语种	英语
WOS记录号	WOS:000357530400001
资助机构	GSSTD
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/178525]
专题	第一临床医学院_期刊论文
通讯作者	Zhao, D (reprint author), Lanzhou Univ, Dept Oncol, Hosp 1, Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China.
推荐引用方式 GB/T 7714	Ling, XL,Zhang, T,Hou, XM,et al. Clinicopathological significance of fascin-1 expression in patients with non-small cell lung cancer[J]. ONCOTARGETS AND THERAPY,2015,8:1589-1595.
APA	Ling, XL,Zhang, T,Hou, XM,Zhao, D,&Zhao, D .(2015).Clinicopathological significance of fascin-1 expression in patients with non-small cell lung cancer.ONCOTARGETS AND THERAPY,8,1589-1595.
MLA	Ling, XL,et al."Clinicopathological significance of fascin-1 expression in patients with non-small cell lung cancer".ONCOTARGETS AND THERAPY 8(2015):1589-1595.