Remote ischaemic conditioning in percutaneous coronary intervention: a meta-analysis of randomised trials

doi:10.5114/pwki.2014.46771

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	Remote ischaemic conditioning in percutaneous coronary intervention: a meta-analysis of randomised trials
	Niu, XW; Zhang, JJ; Chen, D; Wan, GZ; Zhang, YM; Yao, YL; Yao, YL (reprint author), Lanzhou Univ, Hosp 1, Dept Cardiol, 1 Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China.
刊名	POSTEPY W KARDIOLOGII INTERWENCYJNEJ
	2014-12
卷号	10 期号:4 页码:274-282
关键词	remote ischaemic preconditioning remote ischaemic postconditioning percutaneous coronary intervention meta-analysis
ISSN号	1734-9338
DOI	10.5114/pwki.2014.46771
文献子类	Article
英文摘要	Introduction: It remains uncertain whether remote ischaemic conditioning (RIC) using cycles of limb ischaemia-reperfusion as a conditioning stimulus benefits patients undergoing percutaneous coronary intervention (PCI). Aim: We performed a meta-analysis toassessthe effect of RIC in PCI. Material and methods: The PubMed, EMBASE, Web of Science, and CENTRAL databases were searched for randomised controlled trials (RCTs) comparing RIC with controls. The treatment effects were measured as a pooled odds ratio (OR), standardised mean difference (SMD), and corresponding 95% confidence intervals (95% Os) using random-effects models. Results: Fourteen RCTs, including 2,301 patients, were analysed. Compared to the controls, RIC significantly reduced the cardiac enzyme levels (SMD = -0.21; 95% CI: -0.39 to -0.04; p = 0.015; heterogeneity test, I-2 = 75%), and incidence of PCI-related myocardial infarction (OR = 0.70; 95% CI, 0.51-0.98; p = 0.037). There was a trend toward an improvement in the complete ST-segment resolution rate with RIC (OR = 1.83; 95% CI: 0.99-3.40; p = 0.054). No significant difference could be detected between the two groups regarding the risk for acute kidney injury after PCI. Univariate meta-regression analysis suggested that the major source of significant heterogeneity was the PCI type (primary or non-emergent) for the myocardial enzyme levels (adjusted R-2 = 0.44). Subsequent subgroup analysis confirmed the results. Conclusions: The present meta-analysis showed that RIC could confer cardioprotection for patients undergoing coronary stent implantation. Moreover, the decrease in the myocardial enzyme levels was more pronounced in the patients treated with primary PCI.
学科主题	Cardiovascular System & Cardiology
出版地	POZNAN
语种	英语
WOS记录号	WOS:000346042800011
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/125905]
专题	第一临床医学院_期刊论文
通讯作者	Yao, YL (reprint author), Lanzhou Univ, Hosp 1, Dept Cardiol, 1 Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China.
推荐引用方式 GB/T 7714	Niu, XW,Zhang, JJ,Chen, D,et al. Remote ischaemic conditioning in percutaneous coronary intervention: a meta-analysis of randomised trials[J]. POSTEPY W KARDIOLOGII INTERWENCYJNEJ,2014,10(4):274-282.
APA	Niu, XW.,Zhang, JJ.,Chen, D.,Wan, GZ.,Zhang, YM.,...&Yao, YL .(2014).Remote ischaemic conditioning in percutaneous coronary intervention: a meta-analysis of randomised trials.POSTEPY W KARDIOLOGII INTERWENCYJNEJ,10(4),274-282.
MLA	Niu, XW,et al."Remote ischaemic conditioning in percutaneous coronary intervention: a meta-analysis of randomised trials".POSTEPY W KARDIOLOGII INTERWENCYJNEJ 10.4(2014):274-282.