Tanshinone IIA Downregulates HMGB1 and TLR4 Expression in a Spinal Nerve Ligation Model of Neuropathic Pain

doi:10.1155/2014/639563

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	Tanshinone IIA Downregulates HMGB1 and TLR4 Expression in a Spinal Nerve Ligation Model of Neuropathic Pain
	Ma, YQ; Chen, YR; Leng, YF; Wu, ZW; Chen, YR (reprint author), Peoples Hosp Gansu Prov, Dept Urol, Lanzhou 730000, Gansu, Peoples R China.
刊名	EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
	2014
页码	-
ISSN号	1741-427X
DOI	10.1155/2014/639563
文献子类	Article
英文摘要	Fifty-four Sprague-Dawley rats weighing 200 similar to 240 g were randomly divided into sham-operated group (sham group), vehicle-treated SNL group (model group), and Tan IIA-treated SNL group (Tan IIA group). Tan IIA was administered intraperitoneally to rats in the Tan IIA-treated group at a dose of 30 mg/kg daily for 14 days after SNL surgery. Paw withdrawal mechanical thresholds (PWTs) and paw withdrawal thermal latencies (PWLs) were measured. High-mobility group box 1 (HMGB1) and Toll-like Receptor 4 (TLR4) mRNA and protein expression in the spinal cord were measured. Tumour necrosis factor alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), and interleukin-10 (IL-10) in the spinal cord were measured, too. Both the mechanical and heat pain thresholds were significantly decreased. After Tan IIA treatment, HMGB1, and TLR4 mRNA and protein levels, the expression of TNF-alpha and IF-1 beta was reduced significantly. In conclusion, Tanshinone IIA reversed SNL-induced thermal hyperalgesia and mechanical allodynia and downregulated HMGB1 and TLR4 levels and inhibited the HMGB1-TLR4 pathway. Tanshinone IIA inhibited TNF-alpha and IL-1 beta expression but not IF-10 expression in the spinal cords of SNL rats. These results indicate that Tanshinone IIA inhibited SNL-induced neuropathic pain via multiple effects, and targeting the HMGB1-TLR4 pathway could serve as the basis of new antinociceptive agents.
学科主题	Integrative & Complementary Medicine
出版地	NEW YORK
语种	英语
WOS记录号	WOS:000339203400001
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/125873]
专题	第一临床医学院_期刊论文
通讯作者	Chen, YR (reprint author), Peoples Hosp Gansu Prov, Dept Urol, Lanzhou 730000, Gansu, Peoples R China.
推荐引用方式 GB/T 7714	Ma, YQ,Chen, YR,Leng, YF,et al. Tanshinone IIA Downregulates HMGB1 and TLR4 Expression in a Spinal Nerve Ligation Model of Neuropathic Pain[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2014:-.
APA	Ma, YQ,Chen, YR,Leng, YF,Wu, ZW,&Chen, YR .(2014).Tanshinone IIA Downregulates HMGB1 and TLR4 Expression in a Spinal Nerve Ligation Model of Neuropathic Pain.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,-.
MLA	Ma, YQ,et al."Tanshinone IIA Downregulates HMGB1 and TLR4 Expression in a Spinal Nerve Ligation Model of Neuropathic Pain".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2014):-.