Osteopontin expression is associated with platinum-based chemotherapy response and prognosis of patients with advanced non small cell lung cancer

CORC > 兰州大学 > 兰州大学 > 第一临床医学院 > 期刊论文

	Osteopontin expression is associated with platinum-based chemotherapy response and prognosis of patients with advanced non small cell lung cancer
	Zhang, T; Zhang, DM; Zhao, D; Hou, XM; Yang, TN; Zhang, T (reprint author), Lanzhou Univ, Hosp 1, Dept Oncol, 1 Donggang West Rd, Lanzhou 73000, Peoples R China.
刊名	JOURNAL OF BUON
	2014-07
卷号	19 期号:3 页码:742-748
关键词	carcinoma non-small cell lung osteopontin platinum-based chemotherapy response
ISSN号	1107-0625
文献子类	Article
英文摘要	Purpose: To examine the expression of osteopontin (OPN) in patients with advanced non-small cell lung cancer (NSCLC), and to analyze the correlation of the expression level of OPN with response to platinum-based chemotherapy and the prognosis of NSCLC patients. Methods: This retrospective study enrolled 92 patients with advanced NSCLC. All of the patients received platinum-based regimens as first-line chemotherapy. The expression of OPN in advanced NSCLC tissue was detected by immunohistochemistry. The associations between OPN expression with response to chemotherapy and the prognosis were analyzed by SPSS 17.0 statistical software. Results: The positive expression rate of OPN in advanced NSCLC tissue was 36.9% (34/92). The positive expression rate of OPN was higher in patients >= 70 years old (65.2%;15/23) vs those aged <70 years (27.5%;19/69; p<0.05), which was also higher in patients with distant metastasis (51.9%;28/54) than that in patients without metastasis 15.8% (6/38), the difference with statistically significant (p<0.05). Pearson's correlation analysis results showed that OPN expression was significantly correlated with age (r=0.338, p=0.001), distant metastasis (r=0.368, p<0.001), curative effect of platinum-based regimen (r=0.403, p<0.001), progression-free survival/PFS (r=-0.486, p<0.001) and overall survival/OS (r=-0.552, p<0.001). Furthermore, the OPN expression was an independent predictor of PFS and OS for patients with advanced NSCLC after receiving platinum-based first-line chemotherapy (p<0.001). Conclusion: OPN expression is an independent predictor of response to platinum-based first-line chemotherapy and of the prognosis of patients with advanced NSCLC.
学科主题	Oncology
出版地	ATHENS
语种	英语
WOS记录号	WOS:000342963300022
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/125857]
专题	第一临床医学院_期刊论文
通讯作者	Zhang, T (reprint author), Lanzhou Univ, Hosp 1, Dept Oncol, 1 Donggang West Rd, Lanzhou 73000, Peoples R China.
推荐引用方式 GB/T 7714	Zhang, T,Zhang, DM,Zhao, D,et al. Osteopontin expression is associated with platinum-based chemotherapy response and prognosis of patients with advanced non small cell lung cancer[J]. JOURNAL OF BUON,2014,19(3):742-748.
APA	Zhang, T,Zhang, DM,Zhao, D,Hou, XM,Yang, TN,&Zhang, T .(2014).Osteopontin expression is associated with platinum-based chemotherapy response and prognosis of patients with advanced non small cell lung cancer.JOURNAL OF BUON,19(3),742-748.
MLA	Zhang, T,et al."Osteopontin expression is associated with platinum-based chemotherapy response and prognosis of patients with advanced non small cell lung cancer".JOURNAL OF BUON 19.3(2014):742-748.