Prognostic power of abnormal cytogenetics for multiple myeloma: a multicenter study in China

doi:10.3760/cma.j.issn.0366-6999.2012.15.004

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	Prognostic power of abnormal cytogenetics for multiple myeloma: a multicenter study in China
	Lai, YY; Huang, XJ; Cai, Z; Cao, XS; Chen, FP; Chen, XQ; Chen, BA; Fang, MY; Feng, JF; Fu, WL
刊名	CHINESE MEDICAL JOURNAL
	2012-08-05
卷号	125 期号:15 页码:2663-2670
关键词	cytogenetics multiple myeloma in situ hybridization fluorescence
ISSN号	0366-6999
DOI	10.3760/cma.j.issn.0366-6999.2012.15.004
文献子类	Article
英文摘要	Background Chromosomal abnormalities have been shown to play an important prognostic role in multiple myeloma (MM). Interphase fluorescence in situ hybridization (i-FISH) has been much more effective to identify cytogenetic aberrations in MM than conventional cytogenetic technique (CC). To clearly determine the cytogenetic features of Chinese MM patients and identify their prognostic implications, we designed a multicenter study based on i-FISH including 672 patients from 52 hospitals in China. Methods All 672 patients were systematically screened for the following genomic aberrations: del(13q), IgH rearrangement, del(p53) and 1q21 amplifications. Results The analysis showed that the chromosomal changes were detected in 22.1% patients by CC and in 82.3% patients by i-FISH. The most common abnormalities by CC were chromosome 1 aberrations (48.4%), -13/13q- (37.6%), hyperdiploidy (36.6%), hypodiploidy (30.1%) and IgH rearrangements (23.7%). The most frequent abnormalities by FISH was del(13q), which was found in 60.4% patients, whereas IgH rearrangement, 1q21 amplification and p53 deletions were detected in 57.6%, 49.0% and 34.7% cases, respectively. By statistical analysis, -13/13q- by CC was associated with low level of platelet (P=0.015), hyperdiploidy was associated with low level of serum albumin (P=0.028), and IgH rearrangement by FISH was associated with high level of 82 microglobulin (P=0.019). Moreover, 1q21 amplification and del(p53) by FISH conferred a high incidence of progressive disease (PD) after initial therapy. Metaphase detection of IgH rearrangements and chromosome 1 aberrations concurrently was associated with a short progression free survival (PFS) (P=0.036). No significant prognostic implications of other cytogenetic abnormalities were found associated with overall survival and PFS. Conclusions Chinese MM patients had similar cytogenetic abnormalities compared with the previous reported studies. However, the prognostic significance of FISH aberrations were not clearly determined and further study is required. Chin Med J 2012;125(15):2663-2670
学科主题	General & Internal Medicine
出版地	BEIJING
项目编号	China Ministry of Public Health [WKJ2007-3-001]
语种	英语
CSCD记录号	CSCD:4587974
WOS记录号	WOS:000307677700004
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/125758]
专题	第一临床医学院_期刊论文
通讯作者	Huang, XJ (reprint author), Peking Univ, Inst Hematol, Peoples Hosp, Beijing 100044, Peoples R China.
推荐引用方式 GB/T 7714	Lai, YY,Huang, XJ,Cai, Z,et al. Prognostic power of abnormal cytogenetics for multiple myeloma: a multicenter study in China[J]. CHINESE MEDICAL JOURNAL,2012,125(15):2663-2670.
APA	Lai, YY.,Huang, XJ.,Cai, Z.,Cao, XS.,Chen, FP.,...&Huang, XJ .(2012).Prognostic power of abnormal cytogenetics for multiple myeloma: a multicenter study in China.CHINESE MEDICAL JOURNAL,125(15),2663-2670.
MLA	Lai, YY,et al."Prognostic power of abnormal cytogenetics for multiple myeloma: a multicenter study in China".CHINESE MEDICAL JOURNAL 125.15(2012):2663-2670.