The cardiovascular inhibition functions of hydrogen sulfide within the nucleus tractus solitarii are mediated by the activation of K-ATP channels and glutamate receptors mechanisms

doi:10.1691/ph.2011.0821

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	The cardiovascular inhibition functions of hydrogen sulfide within the nucleus tractus solitarii are mediated by the activation of K-ATP channels and glutamate receptors mechanisms
	Qiao, W; Yang, L; Li, XY; Cao, N; Wang, WZ; Chai, C; Lu, Y; Lu, Y (reprint author), SanAiTang Hosp, Dept Clin Lab, 74 Jing Ning Rd, Lanzhou 730030, Peoples R China.
刊名	PHARMAZIE
	2011-04
卷号	66 期号:4 页码:287-292
ISSN号	0031-7144
DOI	10.1691/ph.2011.0821
文献子类	Article
英文摘要	Hydrogen sulfide (H2S), the colorless gas with the smell of rotten eggs, has been regarded as a novel gaseous signaling molecule. Although H2S has been proved been involved into the cardiovascular functions, the cardiovascular functions of H2S within the nucleus tractus solitarii (NTS) are not clear. Unilateral microinjection of NaHS (2 to 200 pmol), a H2S donor, into the NTS caused transient and dose-dependent hypotension and bradycardia (P < 0.01). Microinjection of CBS allosteric activator S-ademetionine (SAM) into the NTS also produced significant decreases in BP (from 101 +/- 8 to 82 +/- 7 mmHg, P < 0.01) and HR (from 469 +/- 16 to 449 +/- 14 bpm, P < 0.01), which was very similar to those of NaHS. Pretreatment with hydroxylamine, a CBS inhibitor, failed to affect the cardiovascular functions of intra-NTS NaHS. However, pretreatment with glibenclamide (10 nmol), a KATp channel blocker, eliminated the on BP (from -23 +/- 4 to -5 +/- 1 mmHg, P< 0.01) and HR (from -24 +/- 2 to -5 +/- 1 bpm, P < 0.01) by 78% and 79%, respectively, of intra-NTS NaHS (20 pmol). Likewise, pretreatment with kynurenic acid (Kyn, 5 nmol) also attenuated the effects of NaHS on BP (from -29 +/- 3 to -12 +/- 3 mmHg, P < 0.01) and HR (from 19 2 to 9 2 bpm, P < 0.01) by 59% and 53%, respectively, of intra-NTS NaHS (20 pmol). These data support the hypothesis that endogenous H2S produces cardiovascular inhibition functions in the NTS, mainly mediated by K-ATP channels regulation or/and glutamate receptors.
学科主题	Pharmacology & Pharmacy ; Chemistry
出版地	ESCHBORN
资助项目	国家自然科学基金项目 ; 中央高校基本科研业务费专项资金
项目编号	National Natural Science Foundation of China [30700266] ; Fundamental Research Funds for the Central Universities [Izujbky-2010-146]
语种	英语
WOS记录号	WOS:000290186500009
资助机构	NSFC ; LZU
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/125721]
专题	第一临床医学院_期刊论文
通讯作者	Lu, Y (reprint author), SanAiTang Hosp, Dept Clin Lab, 74 Jing Ning Rd, Lanzhou 730030, Peoples R China.
推荐引用方式 GB/T 7714	Qiao, W,Yang, L,Li, XY,et al. The cardiovascular inhibition functions of hydrogen sulfide within the nucleus tractus solitarii are mediated by the activation of K-ATP channels and glutamate receptors mechanisms[J]. PHARMAZIE,2011,66(4):287-292.
APA	Qiao, W.,Yang, L.,Li, XY.,Cao, N.,Wang, WZ.,...&Lu, Y .(2011).The cardiovascular inhibition functions of hydrogen sulfide within the nucleus tractus solitarii are mediated by the activation of K-ATP channels and glutamate receptors mechanisms.PHARMAZIE,66(4),287-292.
MLA	Qiao, W,et al."The cardiovascular inhibition functions of hydrogen sulfide within the nucleus tractus solitarii are mediated by the activation of K-ATP channels and glutamate receptors mechanisms".PHARMAZIE 66.4(2011):287-292.