Bioengineered skin in diabetic foot ulcers

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	Bioengineered skin in diabetic foot ulcers
	Teng, YJ; Li, YP; Wang, JW; Yang, KH; Zhang, YC; Wang, YJ; Tian, JH; Ma, B; Wang, JM; Yan, X
刊名	DIABETES OBESITY & METABOLISM
	2010-04
卷号	12 期号:4 页码:307-315
关键词	BS DFU meta-analysis tissues-engineered skin
ISSN号	1462-8902
文献子类	Article
英文摘要	Design and Methods: Comprehensive search strategies of various electronic databases were used for this study to evaluate the effectiveness and safety between BS and conventional treatment (CT) in patients with DFU, and only randomized controlled trials were adopted in our review. Search terms included 'bioengineered skin', 'tissue-engineering skin', 'human-tissue graft', 'human-skin device', 'living-skin equivalent' and 'diabetic foot', 'diabetic ulcer', 'diabetic wound'. Analysis outcomes included complete wound closure, complications, ulcer recurrence and adverse severe events (ASEs). Results: Seven randomized controlled trials on BS vs. CT were included, and 880 participants met inclusion criteria. Pooled analysis showed a significant effectiveness and safety advantages for BS treatment compared to CT for patients with DFUs. In analysis of complications, only statistically significant difference of infection was noted. And no included trials reported ASEs related to these treatments. Conclusions: Based on the meta-analysis, patients with DFUs may benefit from the BS because of its high effectiveness and safety and reduced risk for infections in comparison to CT.
学科主题	Endocrinology & Metabolism
出版地	MALDEN
资助项目	中央高校基本科研业务费专项资金
项目编号	First Hospital of Lanzhou University
语种	英语
WOS记录号	WOS:000274939400004
资助机构	LZU
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/125697]
专题	第一临床医学院_期刊论文
通讯作者	Yan, X (reprint author), Lanzhou Univ, Hosp 1, Lanzhou 730000, Gansu, Peoples R China.
推荐引用方式 GB/T 7714	Teng, YJ,Li, YP,Wang, JW,et al. Bioengineered skin in diabetic foot ulcers[J]. DIABETES OBESITY & METABOLISM,2010,12(4):307-315.
APA	Teng, YJ.,Li, YP.,Wang, JW.,Yang, KH.,Zhang, YC.,...&Yan, X .(2010).Bioengineered skin in diabetic foot ulcers.DIABETES OBESITY & METABOLISM,12(4),307-315.
MLA	Teng, YJ,et al."Bioengineered skin in diabetic foot ulcers".DIABETES OBESITY & METABOLISM 12.4(2010):307-315.